Publications by authors named "Azeez A Aileru"
Ouabain (Oua)-induced hypertension in rodents provides a model to study cardiovascular changes associated with human hypertension. We examined vascular function in rats after a long-term treatment with Oua. Systolic blood pressure was measured by tail-cuff plethysmography in male Sprague-Dawley rats treated with Oua (≈ 25 µg/d) or placebo for 8 weeks.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how the PI3K signaling pathway affects blood pressure in hypertensive rats compared to normal rats, focusing on the nucleus tractus solitarii (NTS).
- Microinjecting PI3K inhibitors like wortmannin and LY294002 into the NTS of hypertensive rats led to significant decreases in mean arterial pressure (MAP) and improvements in baroreflex sensitivity (BRS) and heart rate variability (HRV).
- In contrast, the same injections did not have any effect in control rats, highlighting the role of the PI3K pathway in regulating blood pressure in genetically altered hypertensive rats.
Hypertension in (mRen2)27 transgenic rats is partly dependent on activation of the sympathetic nervous system, but the role of ganglionic transmission is unknown. We assessed indices of synaptic plasticity (post-tetanic short-term potentiation [PTP] and long-term potentiation [LTP]) and sympathetic ganglionic transmission without tetany in superior cervical ganglia (SCG) of Hannover Sprague-Dawley rats (HnSD) versus (mRen2)27 rats. There were no differences in decay time constants [PTP=9 minutes; LTP=120 to 150 minutes in both (mRen2)27 and HnSD].
View Article and Find Full Text PDF