Publications by authors named "Azam Aslemarz"
Article Synopsis
- EpCAM and Trop2 are cell surface markers linked to carcinoma, affecting myosin-based cell behaviors essential for adhesion and migration, but their specific roles in cancer metastasis are not well understood.
- The study uses MCF7 breast cancer cell spheroids to explore how different levels of EpCAM and Trop2 influence cell spreading and cohesion, revealing that depleting EpCAM promotes spreading while depleting Trop2 inhibits it.
- The findings suggest that EpCAM and Trop2 work together to regulate cell contractility and adhesion by affecting cortical tension at cell interfaces, indicating their potential function as a mechanostat that modulates cell behavior in cancer progression.
EpCAM cellular functions in adhesion and migration, and potential impact on invasion: A critical review.
Biochim Biophys Acta Rev Cancer
December 2020
EpCAM has long been known as a cell surface protein highly expressed in carcinomas. It has since become one of the key cancer biomarkers. Despite its high fame, its actual role in cancer development is still controversial.
View Article and Find Full Text PDFAngiogenesis targeting is an attractive approach for cancer treatment. Vascular endothelial growth factor receptor 2 (VEGFR2) is such an important target that is overexpressed in tumor vasculature compared to the endothelium cells of resting blood vessels and blocking of its signaling inhibits neovascularization and tumor metastasis. Immunotoxins represent a promising group of targeted therapeutics to combat tumors.
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