Needle in the heart. Management of penetrating foreign body in an intracardiac chamber: A case report and scoping literature review.

Introduction: Penetrating thoracic trauma with retained foreign bodies, such as needles, is rare. These injuries present management challenges due to diverse aetiologies and potential complications, including tension pneumothorax, cardiac tamponade, and major haemorrhage. Cardiac penetration can result in arrhythmias, ischaemia, valvular and septal defects.

Iodinated contrast prior to thrombolysis was not associated with worse intracranial hemorrhage.

Objectives: The objective was to assess relative incidence of clinical adverse effects between patients receiving, and not receiving, iodinated contrast prior to thrombolysis.

Methods: This was a retrospective registry review of patients presenting to the emergency department treated with recombinant tissue-type plasminogen activator (rt-PA) for acute ischemic stroke between 2004 and 2012. The authors compared the occurrence of all grades of intracranial hemorrhage (ICH), symptomatic intracranial hemorrhage (sICH), and in-hospital deaths between patients undergoing computed tomographic angiography (CTA) prior to thrombolysis and those who did not.

Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9.

Regulated intramembrane proteolysis (RIP) is the primary signaling mechanism for some receptors, such as Notch and the amyloid precursor protein. In addition, some receptor type tyrosine kinases, such as HER4, are able to signal via both kinase activation and regulated receptor proteolysis. Previously, we showed that the IFNaR2 subunit of the type I interferon receptor can be cleaved in a two step process that resembles RIP and that the IFNaR2 intracellular domain (IFNaR2-ICD) can mediate gene transcription in a Stat2 dependent manner.