Publications by authors named "Azalea Khan"
The spleen is prone to both physical damage and functional impairment, which can be difficult to detect before catastrophic complications occur. Currently available tests of splenic function are laborious, user-dependent and unreliable, so there is an unmet need for a reliable test offered routinely in diagnostic laboratories. In this study, we have assessed a simple flow cytometry-based method measuring high mannose glycans (HMGs) on erythrocytes, which has previously been proposed as a potential test of splenic function.
View Article and Find Full Text PDFExosomes or small extracellular vesicles (sEVs) are increasingly gaining attention for their potential as drug delivery systems and biomarkers of disease. Therefore, it is important to understand their biodistribution using imaging techniques that allow tracking over time and at the whole-body level. Positron emission tomography (PET) allows short- and long-term whole-body tracking of radiolabeled compounds in both animals and humans and with excellent quantification properties compared to other nuclear imaging techniques.
View Article and Find Full Text PDFExtracellular vesicles (EVs) such as exosomes and microvesicles have gained recent attention as potential biomarkers of disease as well as nanomedicinal tools, but their behaviour remains mostly unexplored. In order to gain knowledge of their biodistribution it is important to develop imaging tools that allow us to track EVs over time and at the whole-body level. Radionuclide-based imaging (PET and SPECT) have properties that allow us to do so efficiently, mostly due to their high sensitivity, imaging signal tissue penetration, and accurate quantification.
View Article and Find Full Text PDFArticle Synopsis
- * A new formulation for [Zr]Zr-oxine was developed, allowing for a quick, one-step radiolabelling process of white blood cells (WBC) that demonstrated stability for a week.
- * Despite achieving a decent labelling efficiency of nearly 49% for [Zr]Zr-oxine, it was notably lower than the 89% efficiency of [In]In-oxine, although both
Background And Objectives: This report describes a method for producing anatomically detailed, low-cost ultrasound phantoms of the spine with 3-dimensional printing. An implementation that involves representing a portion of the lumbar spine and the ligamentum flavum with 2 different printing materials and the surrounding soft tissues with agar gel is presented.
Methods: A computed tomography image volume of a patient with normal spinal anatomy was segmented to isolate the spine.