Publications by authors named "Azadeh-Sadat Nazouri"
Background & Objective: Breast cancer is the leading cause of cancer related death in females. Sphingosine kinase 1 (SPHK1) and its product sphingosine-1-phosphate (S1P) are the essential key regulator molecules in breast cancer through their ability to promote cell proliferation, angiogenesis, cell proliferation, and lymphagiogenesis. is overexpressed in multiple types of cancer including breast cancer and is associated with resistance to treatment.
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- Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, and the role of hyperandrogenism and the steroidogenic acute regulatory protein (StAR) in its development is important, particularly due to certain genetic variations (polymorphisms) in the StAR gene.* -
- This study aimed to explore the connection between seven specific StAR gene polymorphisms and PCOS by examining 45 women with PCOS and two control groups (infertile women and fertile women) using a restriction fragment length polymorphism (PCR-RFLP) method.* -
- Results indicated that one specific variant (rs137852689) was more common in PCOS patients compared to the control groups,