Trends in Palliative Care Telephone Consultation Support for Health Care Professionals: A Dutch Nationwide Registry between 2004 and 2019.

Regional palliative care consultation (PCC) teams aim to support health care professionals by telephone in providing quality palliative care (PC) in the Netherlands. The study aims to assess trends in the number and characteristics of PC telephone consultations in the Netherlands between 2004 and 2019. A retrospective observational study reviewed data from the Dutch national register for PC consultations by telephone (PRADO).

Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics.

Understanding the role of Tau protein aggregation in the pathogenesis of Alzheimer's disease is critical for the development of new Tau-based therapeutic strategies to slow or prevent dementia. We tested the hypothesis that Tau pathology is associated with functional organization of widespread neurophysiological networks. We used electro-magnetoencephalography with [F]AV-1451 PET scanning to quantify Tau-dependent network changes.

Imaging Aβ and tau in early stage Alzheimer's disease with [F]AV45 and [F]AV1451.

Background: AD is a progressive neurodegenerative disorder that is associated with the accumulation of two different insoluble protein aggregates, Aβ plaques and hyperphosphorylated tau. This study aimed to investigate the optimal acquisition and quantification of [F]AV45 and [F]AV1451 to image Aβ and tau, respectively, in subjects with AD. Fifteen subjects with early stage AD underwent a T1-weighted structural MRI and two dynamic PET scans to image Aβ (60 min, [F]AV45) and tau (120 min, [F]AV1451).

PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers.

Background: Combining PET amyloid-β (Aβ) and tau imaging may be critical for tracking disease progression in Alzheimer's disease (AD).

Objective: We sought to characterize the relationship between Aβ and tau ligands as well as with other measures of pathology.

Methods: We conducted a multi-center observational study in early AD (MMSE >20) participants aged 50 to 85 y.

Insight on automated lesion delineation methods for PET data.

Background: Defining tumour volume for treatment response and radiotherapy planning is challenging and prone to inter- and intra-observer variability. Various automated tumour delineation methods have been proposed in the literature, each having abilities and limitations. Therefore, there is a need to provide clinicians with practical information on delineation method selection.

Quantification of intracranial aneurysm morphodynamics from ECG-gated CT angiography.

Rationale And Objectives: Aneurysm morphodynamics is potentially relevant for assessing aneurysm rupture risk. A method is proposed for automated quantification and visualization of intracranial aneurysm morphodynamics from electrocardiogram (ECG)-gated computed tomography angiography (CTA) data.

Materials And Methods: A prospective study was performed in 19 aneurysms from 14 patients with diagnostic workup for recently discovered aneurysms (n = 15) or follow-up of untreated known aneurysms (n = 4).

Intracranial aneurysm segmentation in 3D CT angiography: method and quantitative validation with and without prior noise filtering.

Intracranial aneurysm volume and shape are important factors for predicting rupture risk, for pre-surgical planning and for follow-up studies. To obtain these parameters, manual segmentation can be employed; however, this is a tedious procedure, which is prone to inter- and intra-observer variability. Therefore there is a need for an automated method, which is accurate, reproducible and reliable.

Withdrawal of statins and risk of subarachnoid hemorrhage.

Background And Purpose: Vascular endothelium, which can be affected by statins, is believed to play a substantial role in subarachnoid hemorrhage (SAH). Our objective was to estimate the association between use and withdrawal of statins and the risk of SAH.

Methods: We conducted a population-based case-control study within the PHARMO database.