Publications by authors named "Ayumi Uesugi"
Article Synopsis
- - Early weaning (EW) in mice leads to increased anxiety and stress responses in adulthood, affecting both behavior and immune function.
- - Mice subjected to EW showed significant differences in behavior tests compared to normally weaned (NW) mice, along with notable changes in their gut microbiome composition, specifically reduced Erysipelotrichaceae.
- - Germ-free mice colonized with gut microbiota from EW mice exhibited higher depressive behaviors and altered immune cell profiles, indicating that changes in gut microbiota due to EW can influence mood and immunity.
The clearance of tissue debris by microglia is a crucial component of maintaining brain homeostasis. Microglia continuously survey the brain parenchyma and utilize extracellular nucleotides to trigger the initiation of their dynamic responses. Extracellular uridine diphosphate (UDP), which leaks or is released from damaged neurons, has been reported to stimulate the phagocytotic activity of microglia through P2Y(6) receptor activation.
View Article and Find Full Text PDFMicroglia are major immunocompetent cells in the central nervous system and retain highly dynamic motility. The processes which allow these cells to move, such as chemotaxis and phagocytosis, are considered part of their functions and are closely related to purinergic signaling. Previously, we reported that the activation of the P2Y(6) receptor by UDP stimulation in microglia evoked dynamic cell motility which enhanced their phagocytic capacity, as reported by Koizumi et al.
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