Publications by authors named "Ayumi Itoh"
In situ XAFS-XRD study of the Zr-YO interaction at extra-high temperatures.
J Synchrotron Radiat
July 2024
Article Synopsis
- A new in situ measurement technique for studying metal/metal-oxide mixtures at extreme temperatures (over 2000 K) was developed to enhance nuclear safety engineering.
- The researchers successfully conducted simultaneous XAFS-XRD measurements to track Zr oxidation and the ZrO-YO reaction over a range of temperatures (up to 2519 K), revealing significant chemical shifts.
- The study also explored the temperature effects on local structure dynamics, comparing experimental data with theoretical models, and proposed potential applications for analyzing nuclear fuel materials like UO-Zr.
Article Synopsis
- The study investigates how prematurity, intrauterine growth restriction (IUGR), and neonatal stress impact intellectual impairment in children with very low birth weight (VLBW).
- It involved a national cohort of 248 VLBW children in Japan, assessing their IQ/DQ at age 3 or older and using structural equation modeling to analyze influential factors.
- Findings revealed that neonatal stress had the strongest negative impact on IQ/DQ, more so than IUGR and prematurity, highlighting the need for strategies to reduce neonatal stress and monitor fetal growth during pregnancy.
Colorectal cancer is one of the most common malignancies in developed countries and chemotherapy is the standard treatment option for advanced colorectal cancer. Identification of biomarkers for predicting response to uracil/ftorafur plus leucovorin (UFT/LV) chemotherapy is an important issue in colorectal cancer treatment. Organic anion transporter 2 (OAT2) and reduced folate carrier 1 (RFC1) are the major uptake transporters of 5-fluorouracil (5-FU) and LV, respectively.
View Article and Find Full Text PDFPaclitaxel and carboplatin (TC) chemotherapy is an effective and well-tolerated regimen against advanced endometrial cancer. Organic anion transporting polypeptide 1B3 (OATP1B3) and copper transporter 1 (CTR1) are critical for the uptake of paclitaxel and carboplatin, respectively. This study aimed to address the prognostic impact of OATP1B3 and CTR1 in endometrial cancer patients treated with adjuvant TC chemotherapy.
View Article and Find Full Text PDFKiller lectin-like receptors on natural killer (NK) cells mediate cytotoxicity through glycans on target cells. We prepared recombinant glutathione S-transferase-fused extracellular lectin-like domains (AA 94-231) of natural killer group 2A (NKG2A) (rGST-NKG2A) and NKG2C (rGST-NKG2C) and determined the binding of these receptors to plates coated with heparin-conjugated bovine serum albumin (heparin-BSA) and glycoproteins. rGST-NKG2A and rGST-NKG2C directly bound to heparin-BSA with K(d) values of 20 and 40 nM, respectively.
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