Publications by authors named "Ayumi Ishizawa"
Yakugaku Zasshi
March 2020
Article Synopsis
- Dosage of cisplatin for chemotherapy is adjusted based on creatinine clearance (Ccr) estimated using the Cockcroft-Gault formula, but there are discrepancies in serum creatinine (Scr) levels depending on the testing method used.
- A study found that cervical cancer patients with "false normal" Ccr (lower kidney function but inaccurately categorized due to Scr adjustments) had higher rates of cisplatin dose reductions and more side effects like leukocytopenia and neutropenia.
- The findings emphasize the importance of accurately assessing renal function to ensure proper dosing of cisplatin, ultimately improving patient outcomes and quality of life.
