Publications by authors named "Ayumi Goda"
Background: With advances in the treatment of heart failure with reduced ejection fraction (HFrEF), the prediction of left ventricular reverse remodeling (LVRR) has become increasingly important. Cardiopulmonary exercise testing (CPET) is a non-invasive test recommended for prognostic risk assessment in HFrEF; however, it is not known whether it predicts LVRR. We aimed to investigate whether the parameters obtained from CPET are useful in predicting LVRR in HFrEF.
View Article and Find Full Text PDFBackground: Obesity is a risk factor for heart failure (HF) development but is associated with a lower incidence of mortality in HF patients. This obesity paradox may be confounded by unrecognized comorbidities, including cachexia.
Methods: A retrospective assessment was conducted using data from a prospectively recruiting multicenter registry, which included consecutive acute heart failure patients.
Aims: Atrial fibrillation (AF) leads to impaired exercise capacity, and catheter ablation (CA) for AF improves exercise capacity. However, the precise changes in daily activities after CA for AF remain unclear. The authors aimed to evaluate the changes in daily activities following CA for AF using a wristwatch-type pulse wave monitor (PWM), which tracks steps and exercise time, estimates burnt daily calories, and records sleep duration, in addition to establishing the rhythm diagnosis of AF or non-AF.
View Article and Find Full Text PDFBackground: Preventive management of heart failure (HF) should involve strategies to increase awareness of HF in patients with pre-HF and those at risk of HF. However, the perception of HF in patients with acute coronary syndrome (ACS) remains unclear. This study aimed to assess patient understanding of the definition of HF for the public-that is, its illness trajectory (intermittent decline), impact on life expectancy (HF would limit life expectancy), and symptoms (shortness of breath, swelling)-that was introduced by the Japanese Circulation Society.
View Article and Find Full Text PDFPatients hospitalized for heart failure (HF) experience impairments in functional status, primarily affecting basic activities of daily living (ADL). We investigated the independent effect of functional status for ADL on patient-centered outcomes (i.e.
View Article and Find Full Text PDFBackgrounds: Heart rate (HR) and stroke volume (SV)-the components of cardiac output-have a complementary relationship. Poor HR increase during exercise is associated with poor exercise tolerance in heart failure (HF) with preserved ejection fraction (HFpEF), but its prognostic impact remains unclear. Furthermore, whether the compensation for poor HR increase with SV during exercise is associated with prognosis remains unknown.
View Article and Find Full Text PDFBackground: The efficacy of balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic disease (CTEPD) without pulmonary hypertension (PH) remains unknown. Exercise PH (Ex-PH) is associated with impaired exercise capacity, even when pulmonary hemodynamics are normal at rest. We hypothesized that patients with Ex-PH could be the candidates for BPA.
View Article and Find Full Text PDFA simple method for determining the anaerobic threshold in patients with heart failure (HF) is needed. This prospective clinical trial (LacS-001) aimed to investigate the safety of a sweat lactate-monitoring sensor and the correlation between lactate threshold in sweat (sLT) and ventilatory threshold (VT). To this end, we recruited 50 patients with HF and New York Heart Association functional classification I-II (mean age: 63.
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- Recent European guidelines categorize exercise pulmonary hypertension (ex-PH) as a distinct condition, especially in patients with systemic sclerosis (SSc), yet its clinical characteristics are still not well understood.
- A study analyzed 77 patients with SSc, identifying three groups: overt-PH, ex-PH, and non-PH, based on pulmonary arterial pressure and response during exercise testing.
- Results indicated that exercise tolerance and specific measurements like peak oxygen consumption differ significantly between the groups, suggesting that ex-PH may act as a transitional state between no pulmonary hypertension and overt pulmonary hypertension in SSc patients.
Background: Renin-angiotensin system inhibitors (RASI) reduce adverse cardiovascular events in patients with heart failure (HF) with left ventricular ejection fraction (LVEF) ≤40% and mild or moderate chronic kidney disease (CKD). However, RASI administration rate and its association with long-term outcomes in patients with CKD complicated by HF with LVEF >40% remain unclear.
Methods: We analyzed 1923 consecutive patients with LVEF >40% registered within the multicenter database for hospitalized HF.
Article Synopsis
- Research shows that women with supra-normal left ventricular ejection fraction (snEF) have a higher risk of adverse heart failure outcomes compared to men, particularly in the mildly reduced EF (HFmrEF) category.
- A study involving nearly 4,000 heart failure patients found that women were less likely to receive guideline-directed medical therapy (GDMT) compared to men, which could impact their health outcomes.
- The findings suggest a U-shaped relationship between left ventricular ejection fraction (LVEF) and long-term health risks, indicating the need for sex-specific treatment guidelines to improve heart failure management for women.
Background: Impaired quality of life (QoL) is prevalent among patients with chronic thromboembolic pulmonary hypertension (CTEPH) despite improved survival due to medical advances. We clarified the physical QoL of patients with CTEPH with mildly elevated pulmonary hemodynamics and evaluated its determinants using a database of patients with CTEPH evaluated for hemodynamics during exercise.
Methods: The QoL was measured in 144 patients with CTEPH (age, 66 (58-73) years; men/women, 48/96) with mildly elevated mean pulmonary artery pressure (<30 mm Hg) at rest after treatment with balloon pulmonary angioplasty and/or pulmonary endarterectomy using the Short-Form 36 (SF-36) questionnaire.
Article Synopsis
- Researchers wanted to know how patients with pulmonary hypertension (PH) like to be involved in decisions about their treatment.
- They found that most patients preferred doctors to suggest treatment options but also wanted to be somewhat involved in the decision-making process.
- The biggest factor for patients when deciding on treatment was reducing symptoms, and many valued doctors' recommendations more than their own personal values in treatment choices.
Article Synopsis
- Over an 11-year period, a study analyzed trends in clinical management and outcomes for 6,877 hospitalized patients with heart failure (HF).
- The average age of patients increased from 75.2 to 76.4 years, while the proportion of those with heart failure with reduced ejection fraction (HFrEF) remained stable, and hospital stays lengthened.
- Notably, the 1-year mortality rate dropped significantly for HFrEF patients, from 18.0% to 9.3%, indicating improved long-term outcomes, while mortality for non-HFrEF patients showed no significant change.
Article Synopsis
- Intravenous epoprostenol is effective for improving exercise capacity and survival in pulmonary arterial hypertension (PAH) patients but comes with notable side effects.
- A study reviewed patients who switched from epoprostenol to treprostinil due to intolerable side effects, finding that transitioning improved their condition and comfort.
- The findings suggest that switching to treprostinil can enhance treatment adherence and provide better long-term management for PAH patients facing adverse effects from epoprostenol.
Background: In pulmonary hypertension (PH), pulmonary artery pressure (PAP) does not increase to pulmonary perfusion (PP) < 50%. During exercise, PAP may be increased even at PP > 50% for the early detection of PP disorders. The relationship between PP estimated by pulmonary angiography (PAG) and PAP was evaluated in patients with chronic thromboembolic PH (CTEPH) treated by balloon pulmonary angioplasty with near-normal PH.
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- The main symptom for diagnosing pulmonary arterial hypertension (PAH) is difficulty breathing during physical activity, which also leads to lower exercise ability in patients.
- A study with 82 patients found that various predictors, like peak cardiac output and oxygen content difference, significantly affect exercise capacity and ventilatory efficiency even after medical treatment.
- The research concluded that both central factors (like heart function) and peripheral factors (like muscle strength) are linked to the reduced exercise tolerance seen in PAH patients, showing the need for a comprehensive treatment approach.
Article Synopsis
- Pulmonary hypertension (PH) is a serious condition linked to left heart disease (LHD), with two types: isolated post-capillary (Ipc-PH) and combined post-capillary and pre-capillary (Cpc-PH), the latter having a worse outlook.
- The study involved 105 patients with LHD undergoing right heart catheterization and cardiopulmonary exercise testing (CPET), which found that specific CPET indicators could differentiate between Ipc-PH and Cpc-PH.
- Key findings showed that patients with Cpc-PH had lower peak carbon dioxide levels and lower oxygen consumption rates during exercise, with these CPET measures being reliable predictors of Cpc-PH compared to Ipc-PH and
Geriatric Nutritional Risk Index (GNRI) is known both as a reliable indicator of nutritional status and a predictor of long-term survival among patients with acute decompensated heart failure (ADHF). However, the optimal timing to evaluate GNRI during hospitalization remains unclear. In the present study, we retrospectively analyzed patients hospitalized with ADHF in the West Tokyo Heart Failure (WET-HF) registry.
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- A study evaluated a wristwatch-type continuous pulse wave monitor (PWM) for detecting asymptomatic atrial fibrillation in high-risk patients and those with known atrial fibrillation.
- The PWM's detection accuracy was high; it had a sensitivity of 98.0% and specificity of 90.6%, diagnosing 48 out of 55 known cases and two in the high-risk group.
- The findings suggest that the wristwatch PWM is a practical tool for screening atrial fibrillation in everyday life, potentially benefiting older patients who struggle with more complex devices.