Plant Flavonoids with Antimicrobial Activity against Methicillin-Resistant (MRSA).

Methicillin-resistant (MRSA) has become a serious threat to human public health and global economic development, and there is an urgent need to develop new antimicrobial agents. Flavonoids are the largest group of plant secondary metabolites, and the anti- and anti-MRSA activities of flavonoids have now been widely reported. The aim of this Review is to describe plant-derived flavonoid active ingredients and their effects and mechanisms of inhibitory activity against MRSA in order to provide insights for screening novel antimicrobial agents.

Development of Membrane-Targeting Fluorescent 2-Phenyl-1-phenanthro[9,10-]imidazole-Antimicrobial Peptide Mimic Conjugates against Methicillin-Resistant .

The escalation of multidrug-resistant bacterial infections, especially infections caused by methicillin-resistant (MRSA), underscores the urgent need for novel antimicrobial drugs. Here, we synthesized a series of amphiphilic 2-phenyl-1-phenanthro[9,10-]imidazole-antimicrobial peptide (AMP) mimic conjugates (-). Among them, compound exhibited excellent antibacterial activity against G+ bacteria and clinical MRSA isolates (MIC = 0.