Print/Press Workflow With a Novel Silicate Ceramic Material: A Case Report.

Digital technology that utilizes 3D printing has become a viable alternative to the traditional fabrication of wax patterns and definitive restorations for pressable ceramics. Digital workflows afford clinicians fewer variables, improved repeatability, and faster design and fabrication times. The print/press technique for producing zirconia-reinforced lithium-disilicate restorations offers benefits in terms of convenience, precision, and improved mechanical properties.

What's Trending in Resin-Based Restorations.

Besides meticulous application of proper bonding protocols and clinical technique, the clinical success of direct resin-based restorations is dependent on the selection of the appropriate restorative material, curing light, and, whenever certain contours of the tooth need to be rebuilt, matrix band system. All of these aspects have seen significant developments and improvements over the years, all geared toward increased clinical success and longevity. Highlighting some of these key developments, this article provides an update on resin-based composites, curing lights, and matrix bands.

Sex differences in the anticompulsive-like effect of memantine: Involvement of nitric oxide pathway but not AMPA receptors.

Memantine, an N-Methyl-D-Aspartate (NMDA) antagonist, has been examined as a potential treatment for Obsessive-Compulsive Disorder (OCD). Yet, there is limited knowledge regarding how it works to reduce compulsive behaviour and whether it has different effects on individuals based on their sex. Herein, we investigated if there are sex differences in the anticompulsive-like effect of memantine in adult Swiss mice.

Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse Models.

Unlabelled: The phosphatases of regenerating liver (PRL) are oncogenic when overexpressed. We previously found that PRL2 deletion increases PTEN, decreases Akt activity, and suppresses tumor development in a partial Pten-deficient mouse model. The current study aims to further establish the mechanism of PTEN regulation by PRL2 and expand the therapeutic potential for PTEN augmentation mediated by PRL2 inhibition in cancers initiated without PTEN alteration.

Impact of Irradiation on the Adhesive Performance of Resin-Based Dental Biomaterials: A Systematic Review of Laboratory Studies.

Head and neck cancers are a significant global health burden, with radiation therapy being a frequently utilized treatment. The aim of this systematic review was to provide a critical appraisal of laboratory studies that assessed the effect of irradiation on the adhesive performance of resin-based biomaterials. The analysis included 23 laboratory studies obtained from five databases, with most studies using human enamel, dentin, or both, and bonding procedures involving the fabrication of direct restorations, standardized specimens, bonding of orthodontic brackets, and luting of endodontic fiber posts.

Implant position and guided placement for in-house-produced CAD/CAM restorations with titanium (Ti)-bases.

Digital dentistry has contributed to the evolution and simplification of dental implantology over the last decade. The incorporation of intraoral scanners, CBCT, 3D implant-planning software, and CAD/CAM systems makes prosthetically driven implantology a straightforward process. Such digital resources for treatment planning and execution, following evidence-based concepts, have the ability to improve the long-term esthetics and function of implant-supported restorations as well the long-term survival of dental implants.

Digital Implant Therapy for the Edentulous Patient.

Numerous treatment modalities describing surgical and prosthetic techniques for treating edentulous patients with dental implants have been published during the past 30 years. With the many recent advancements in software, hardware, and biomaterials, the clinical steps for full-arch guided implant placement, immediate provisionalization, and fabrication of the definitive prosthesis have changed significantly. The use of new digital implant components, intraoral scanners, and 3D printing helps clinicians and dental technicians streamline this treatment modality while reducing chairtime and clinical complications.

Disruption of fertility, placenta, pregnancy outcome, and multigenerational inheritance of hepatic steatosis by organotin exposure from contaminated seafood in rats.

Early life exposure to endocrine-disrupting chemicals (EDCs) is an emerging risk factor for development of complications later in life and in subsequent generations. We previously demonstrated that exposure to the EDC organotin (OT), which is present in contaminated seafood, resulted in reproductive abnormalities in female rats. However, few studies have explored the effect of OT accumulation in seafood on pregnancy outcomes.

An alternative methodology to determine Pb activity soil profiles.

Unsupported Pb (Pb) is generated in air and is subsequently deposited on soil surface. The Pb can be used for sediment dating, soil erosion/sedimentation and air mass studies. In many cases, Pb activity determination (gamma ray 46.

The obesogen tributyltin induces abnormal ovarian adipogenesis in adult female rats.

Tributyltin chloride (TBT) is an obesogen associated with various metabolic and reproductive dysfunctions after in utero exposure. However, few studies have evaluated TBT's obesogenic effect on adult ovaries. In this study, we assessed whether TBT's obesogenic effects resulted in adult ovarian adipogenesis and other reproductive abnormalities.

Using (222)Rn as a tracer of geodynamical processes in underground environments.

Radon levels in two old mines in San Luis, Argentina, were measured and analyzed, with the aim to assess the potential use of this radioactive noble gas as a tracer of geological processes in underground environments. La Carolina gold mine and Los Cóndores tungsten mine are today used as tourism mines. CR-39 nuclear track detectors were used for this purpose.

Temporal evolution of ¹³⁷Cs⁺, K⁺ and Na⁺ in fruits of South American tropical species.

Concentrations of (137)Cs, K and Na in fruits of lemon (Citrus limon B.) and of K and Na in fruits of coconut (Cocos nucifera L.) trees were measured by both gamma spectrometry and neutron activation analysis, with the aim to understand the behaviour of monovalent inorganic cations in tropical plants as well as the plant ability to store these elements.

Assessment of ⁷Be content in precipitation in a South American semi-arid environment.

There are two naturally occurring radiogenic isotopes of beryllium, ⁷Be and ¹⁰Be. These are produced when cosmic radiation interacts with oxygen and nitrogen in the atmosphere. After production, these radionuclides are input to ecosystems through wet and dry deposition.

Influence of crop types and soil properties on radionuclide soil-to-plant transfer factors in tropical and subtropical environments.

This paper presents a descriptive statistical analysis of radionuclide soil-to-plant transfer factors (Fv) for tropical and subtropical environments. These values were collected from previous databases and standard publications with the objective of contributing to the IAEA Technical Report Series: Handbook of parameter values for the prediction of radionuclide transfer to humans in terrestrial and freshwater environments. More than 2200 Fv values of different radionuclides were gathered and arranged into specific databases, detailing relevant information regarding the environments where this parameter was calculated.

Subunit interaction in B19 parvovirus empty capsids.

B19 parvovirus is a small single-stranded DNA virus with a genome that encodes only two structural proteins, designated VP1 and VP2. 60 copies of the structural proteins assemble into the viral capsid, with approximately 95% VP2 and 5% VP1. Recombinant empty capsids composed of VP2 alone or of VP2 and VP1 self-assemble into particles that are morphologically indistinguishable from full virions.

Important aspects concerning evaluation of renal function and blood pressure. Kinins, prostaglandins, lead.

The kallikrein-kinin and prostaglandin-thromboxane-leukotriene systems and the body lead burden all influence renal function and systemic blood pressure to some extent. Because these systems may become generally accepted as more important in assessing renal function and blood pressure in the future, a brief overview of each has been given.

Survival after first recurrence of breast cancer. The Miami experience.

Background: Four hundred thirty-three patients with recurrent breast cancer were treated by the authors at a large medical breast oncology facility from 1976-1982. The median survival time from first relapse (MSFR) for the 193 patients whose survival experience was not confounded by lead-time bias was 26 months. This MSFR is similar to that of most series published in the 1970s and 1980s and is approximately double that of series published in the 1960s.

Nosocomial human parvovirus B19 infection: lack of transmission from a chronically infected patient to hospital staff.

Objective: To assess the potential for nosocomial spread of parvovirus B19 from a chronically infected patient.

Design: Employees exposed to the index case and control (unexposed) employees were evaluated by baseline and follow up parvovirus B19 serologies and hematologic assessments, and completed baseline and follow up epidemiologic questionnaires.

Setting: A chronically infected patient was hospitalized on a hematology ward in a research referral hospital for 3.

Translational regulation of B19 parvovirus capsid protein production by multiple upstream AUG triplets.

The B19 parvovirus produces two capsid proteins in strikingly different quantities (VP1 less than 4%, VP2 greater than 96%) from overlapping RNAs that are derived from the same transcription unit. Immediately upstream from the VP1 translation initiation site is an unusual sequence containing multiple ATG triplets. During RNA processing this sequence is spliced out of VP2 RNA.

The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transfected cells.

The B19 parvovirus is a cause of bone marrow failure in humans. B19 is toxic to erythroid progenitor cells in vitro. Viral products possibly responsible for toxicity were explored by transfection of cloned B19 genome into HeLa cells.

Functional mapping of the genome of the B19 (human) parvovirus by in vitro translation after negative hybrid selection.

We have analyzed the coding capacity of B19 parvovirus transcripts by in vitro translation using the negative hybrid selection technique. Five different antisense oligonucleotides (18-mers) corresponding to different portions of the B19 genome were hybridized to RNA samples extracted from human erythroid bone marrow cells infected with B19 parvovirus in vitro, and RNase H was added to cleave specific B19 RNA molecules at selected sites. B19-specific translation products of these RNA samples were determined by immunoprecipitation.

Novel transcription map for the B19 (human) pathogenic parvovirus.

The B19 parvovirus, a small single-stranded DNA virus of 5.4 kilobases, is pathogenic in humans. B19 has remarkable specificity for erythroid progenitor cells and has been propagated in vitro only with human erythroid bone marrow.