Facile synthesis of Ag@FeO/ZnO nanomaterial for label-free electrochemical detection of methemoglobin in anemic patients.

Methemoglobinemia (MetHb, Fe) is a chronic disease arising from the unequal distribution of oxyhemoglobin (HbFe, OHb) in the blood circulatory system. The oxidation of standard oxyhemoglobin forms methemoglobin, causing cyanosis (skin bluish staining). Methemoglobin cannot bind the pulmonary gaseous ligands such as oxygen (O) and carbon monoxide (CO).