Impaired oxidative balance and association of blood glucose, insulin and HOMA-IR index in migraine.

Introduction: The nature of the relationship between glucose metabolism and occurrence of migraine has not been elucidated precisely. This study investigated the status of oxidative/antioxidative balance and its relationship with the glucose metabolism in migraineurs to get new points of view for the underlying oxidative mechanisms.

Materials And Methods: Sixty migraineurs and 46 control subjects were included in the study.

Increased levels of total oxidant status and decreased activity of arylesterase in migraineurs.

Objectives: There is strong evidence associating migraine with a variety of comorbid disorders, including cardiovascular disease and stroke, in which oxidative stress seems to be an important underlying mechanism. The aim of the study was to investigate in migraineurs the body oxidant/antioxidant balance and paraoxonase enzyme activities as a measure of HDL functionality.

Design And Methods: Oxidative stress index, total oxidant status and antioxidant status were examined in addition to the paraoxonase and arylesterase enzyme activities in sixty-two migraineurs and fifty healthy control subjects.