Selective cytotoxic effects of nitrogen-doped graphene coated mixed iron oxide nanoparticles on HepG2 as a new potential therapeutic approach.

New selective therapeutics are needed for the treatment of hepatocellular carcinoma (HCC), the 7th most common cancer. In this study, we compared the cytotoxic effect induced by the release of pH-dependent iron nanoparticles from nitrogen-doped graphene-coated mixed iron oxide nanoparticles (FeO/N-GN) with the cytotoxic effect of nitrogen-doped graphene (N-GN) and commercial graphene nanoflakes (GN) in Hepatoma G2 (HepG2) cells and healthy cells. The cytotoxic effect of nanocomposites (2.

The role of salivary galectin-3 and galectin-9 levels in plaque-induced gingivitis and periodontitis.

Background: This study aimed to compare the salivary galectin-3 and galectin-9 levels in periodontitis, gingivitis, and periodontally healthy patients.

Methods: This study included 75 non-smokers who were systemically healthy. The clinical periodontal parameters of each participant were recorded.

Prediction of the proximate analysis parameters of refuse-derived fuel based on deep learning approach.

Determination of proximate characteristics can be achieved using conventional analyses methods that require a certain amount of time. In cement factories, refuse-derived fuel (RDF) is continuously fed to a kiln by a conveyor belt, so even if an inappropriate proximate characteristic is determined, it would be too late to prevent the feeding of RDF to the kiln. To overcome this problem, there is a need for instant measurement of the proximate characteristics (moisture, volatile matter, ash) that enables the feeding to be stopped.

Implementation of an early warning system with hyperspectral imaging combined with deep learning model for chlorine in refuse derived fuels.

Chlorine content is one of the most important parameters in Refuse Derived Fuels (RDFs) used as a fuel in cement kilns. The main problem with the use of RDF is that chlorine in the waste weakens the cement, increases the risk of corrosion in the kiln and forms toxic gas emissions. Alternative fuels containing high amounts of chlorine, such as plastic waste should be used in limited quantities with the quality of the kiln used and the cement being should be preserved by preparing the appropriate RDF mixture.

Application of Multi-Criteria Decision analysis including sustainable indicators for prioritization of public transport system.

Paratransit modes dominate the public transportation industry in the majority of developing countries, especially those in Sub-Saharan Africa. The number of these modes has increased rapidly over the years. Authorities have not yet been able to provide a better alternative for passengers, whose demand is ever-growing.

Utilization of liquid product through pyrolysis of LDPE and C/LDPE as commercial wax.

In this study, pyrolysis of low-density polyethylene (LDPE) and LDPE with aluminum (C/LDPE) wastes was carried out with different heating rates (5, 10, 20 °C/min) at different temperatures (400, 600, 800 °C). Product yields of LDPE and C/LDPE wastes were compared, and optimum liquid products were analyzed to utilize as commercial waxes for future use. The properties of pyrolyzed wastes was investigated with proximate, elemental analysis, and TGA.

The effect of energy-saving options on environmental performance of a building: a combination of energy audit-life cycle assessment for a university building.

An energy audit was realized for a building group located on a university campus to measure the environmental sustainability and efficient usage of natural resources. As a result of energy audit, exterior insulation and double-glazing application were came to the front for energy-saving options. Although energy audit provides energy-saving options as output, it is not enough to provide information about how environmental impacts will change if the defined options are used.

Decision-making for the selection of different leachate treatment/management methods: the ANP and PROMETHEE approaches.

Municipal solid waste (MSW) landfill leachate is a highly contaminated liquid effluent. Leachate has a complex nature that needs to be appropriately treated before being discharged into the environment. There are various options for leachate treatment.

A heating value estimation of refuse derived fuel using the genetic programming model.

Refuse Derived Fuel (RDF) makes an increasingly important contribution to sustainable waste management as an energy source in cement kilns. The most important parameter of RDF in an evaluation of its performance as a fuel is Higher Heating Value (HHV). The two methods of HHV determination are the direct method and the indirect method.

Cetuximab and epirubicin HCl-combined application as a possibility to treat both parental and epirubicin HCl-resistant liver cancer cells.

Background And Aims: Targeted chemotherapeutics such as cetuximab can cause many side effects such as skin toxicity when used in high concentrations. In addition, cancer cells can develop resistance to some of the anticancer agents during treatment. The lack of the desired success in chemotherapy and the development of resistance to chemotherapeutics, such as epirubicin HCl, suggest that there is a need for combined therapies.

Evaluation of cytotoxic, membrane, and DNA damaging effects of Thymus revolutus Célak essential oil on different cancer cells.

Background/aim: In this study, we evaluated Thymus revolutus Célak essential oil and its two main constituents, γ-terpinene and p-cymene, as potential oxidative agents against lung cancer and epidermoid carcinoma cells.

Materials And Methods: Cell viability assessment was made by CellTiter-Blue1397904493 cell viability and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay after treatment with 5-600 μg/mL concentrations of essential oil, γ-terpinene, and p-cymene. Malondialdehyde and 8-hydroxy-2'-deoxyguanosine levels in parental H1299, epirubicin-resistant (drug-resistant) H1299, A549, and A431 cells were also assayed after essential oil, γ-terpinene, and p-cymene had been administered for 24 h.

Pyrolysis of Plants After Phytoremediation of Contaminated Soil with Lead, Cadmium and Zinc.

The aim of this study was to remediate lead (Pb), cadmium (Cd) and zinc (Zn) from contaminated soil and stabilize to pyrolysis solid product. To accomplish this, phytoremediation of soil contaminated with Pb, Cd and Zn by different plants (sunflower, corn and rape) was performed with and without ethylenediaminetetraacetic acid (EDTA). According to phytoremediation results, rape was the most effective plant with 72 %, 76 % and 77 % removal efficiency for Pb, Cd and Zn, respectively.

A comparative study of the antioxidant/prooxidant effects of carvacrol and thymol at various concentrations on membrane and DNA of parental and drug resistant H1299 cells.

Carvacrol and thymol, both used as flavor agents in cosmetic and food products, have prooxidant and antioxidant activities. To clarify the mechanisms of their cytotoxicity and the factors affecting their antioxidant/prooxidant activities, we investigated cell membrane and DNA damage induced by carvacrol and thymol in parental and drug-resistant human lung cancer cell lines. After 24 and 48 hour incubation periods, the cytotoxicity of carvacrol (IC50 380 and 244 microM) was found to be higher than that of thymol (IC50 497 and 266 microM) in parental cells.

Evaluation of healthcare waste treatment/disposal alternatives by using multi-criteria decision-making techniques.

Healthcare waste should be managed carefully because of infected, pathological, etc. content especially in developing countries. Applied management systems must be the most appropriate solution from a technical, environmental, economic and social point of view.

Antioxidant and anticancer activity of fresh corm extract from Romulea tempskyana (Iridaceae).

The antioxidant and anticancer properties of a medicinal plant, Romulea tempskyana (R. tempskyana) (Iridaceae) were investigated. The fresh corm water extract of R.

Life cycle assessment of solid waste management options for Eskisehir, Turkey.

Life cycle assessment (LCA) methodology was used to determine the optimum municipal solid waste (MSW) management strategy for Eskisehir city. Eskisehir is one of the developing cities of Turkey where a total of approximately 750tons/day of waste is generated. An effective MSW management system is needed in this city since the generated MSW is dumped in an unregulated dumping site that has no liner, no biogas capture, etc.

Characterization of an urban landfill soil by using physicochemical analysis and solid phase microextraction (SPME)-GC/MS.

We have aimed at characterizing top soil samples taken in-situ from five different locations of the unregulated dumping site in Eskişehir/Turkey for a period of six months. The study is the first attempt in the city and in Turkey, regarding particularly the SPME (Solid Phase Microextraction Technique) analysis method utilized. A comprehensive research has been conducted to produce critical soil data to be used for indicating current risks as well as the urgency of rehabilitating the site and establishing a sanitary landfill in the site.

Characterization of the leachate in an urban landfill by physicochemical analysis and solid phase microextraction-GC/MS.

The aim of this study is to evaluate extensively the characterization and identification of major pollutant parameters by paying attention to the organic chemical pollution for unregulated dumping site leachate in Eskişehir/Turkey. The study that is first and only one research has been very important data related with before new sanitary landfill site in Eskişehir city. For this purpose, in this study leachate samples were collected in-situ at monthly interval for a period of 8 months.

Epirubicin HCl toxicity in human-liver derived hepatoma G2 cells.

Epirubicin HCl is a new anthracycline analog and derivative of doxorubicin. Doxorubicin is a potent anticancer agent, the use of which is limited by its cumulative dose-dependent cardiotoxicity. Epirubicin HCl has more favorable therapeutic index than doxorubicin and possesses less hematologic and cardiac toxicity at comparable doses.