Obesity as a modifying factor of periodontal therapy outcomes: local and systemic adipocytokines and oxidative stress markers.

Objectives: Adipocytokines and oxidative stress (OS) are involved in the pathogenesis of both obesity and periodontitis. The aim of this study was to evaluate periodontal therapy outcomes in terms of serum and gingival crevicular fluid (GCF) levels of adipocytokines and OS markers in obese patients with periodontitis, in order to have an insight into the association between obesity and periodontitis.

Materials And Methods: A total of 39 patients (20 obese, 19 non-obese) with periodontitis were included in this study.

Long-term effects of orchiopexy and orchiectomy on the testes of rats with testicular torsion.

Introduction: Ischemia/reperfusion injury occurs after testicular torsion, levels of free oxygen radicals and inflammatory cytokines are increased in both the torsional and contralateral testis, leading to testicular injury.

Objective: The present study investigated whether orchiopexy or orchiectomy after testicular torsion was superior in terms of fertility potential in the long term.

Study Design: Following 720°, 4 h left testicular torsion, orchiectomy or orchiopexy was performed on 84 rats, which were then sacrificed and evaluated for testicular function at day 1, at 3 months and 6 months (n = 14 per group).

The Prevalence of Pain in the First 24 Hours After Surgery: A Multicenter Study.

Purpose: This study was conducted to determine the prevalence and severity of postoperative pain in the first 24 hours after surgery and to emphasize the importance of postoperative pain assessment.

Design: A descriptive study.

Methods: This study was carried out on May 21, 2019 with 898 patients who had completed the postoperative 24th hour in the surgical clinics of 10 training and research hospitals in Istanbul, the capital of Turkey.

Combinatorial effect of zoledronic acid and irradiation on the prevention of DMBA-induced precancerogenic changes in the mammary tissues of rats.

Background: At present, the rates of breast cancer are continuously increasing, with over a million new cases being diagnosed worldwide each year. Hence, the development of new breast cancer chemopreventive drugs with acceptable efficacy and toxicity that are suitable for use for a protracted period of time is urgently needed. The present study investigated the potential preventive effects of zoledronic acid [ZOL] and radiotherapy [RT], both alone and in combination, on precancerogenic changes on the breast tissues of females.

Effects of Electroconvulsive Therapy on Some Inflammatory Factors in Patients With Treatment-Resistant Schizophrenia.

Objectives: Electroconvulsive therapy (ECT) is the most effective option for several psychiatric conditions, including treatment-resistant schizophrenia. However, little is known about the molecular mechanism of action of ECT. The link between inflammatory system and schizophrenia is the focus of recent studies.

The effect of regular exercise and massage on oxidant and antioxidant parameters.

This experimental study aimed to determine the effects of the combined application of regular exercises and massage on the values of Malondialdehyde (MDA), Nitric Oxide (NOx), Glutathione (GSH), Adenosine Deaminase (ADA) and Superoxide Dismutase (SOD). Twenty five sedentary women (32-50 years) who did not have the habit of getting regularly massages or exercising and participated voluntarily in the study. The subjects were randomly separated into three groups: control group (CG, n = 9), exercise group (EG, n = 8), and massage and exercise group (MEG, n = 8).

Evaluation of salivary total oxidant-antioxidant status and DNA damage of children undergoing fixed orthodontic therapy.

Objective: To determine the total oxidant status (TOS), total antioxidant status (TAS), and the 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and their interrelationship in the saliva of children undergoing fixed orthodontic therapy.

Materials And Methods: Thirty children were randomly divided into three groups. The attachments were bonded to all of the teeth using three different orthodontic composites: Transbond XT, Kurasper F, and GrenGloo.

Apricot attenuates oxidative stress and modulates of Bax, Bcl-2, caspases, NFκ-B, AP-1, CREB expression of rats bearing DMBA-induced liver damage and treated with a combination of radiotherapy.

We evaluated the ability of apricot to attenuate apoptosis and oxidative stress developed during the process of 7,12-dimethylbenz[a]anthracene (DMBA) and radiotherapy in the liver of rats bearing liver damage. Fifty female Wistar rats were divided into 7 groups; (i) normal control rats; (ii) rats fed with standard diet with apricot (20%), (ii) rats fed with standard diet and administrated 6 gray radiotherapy with Co 60 device applied to a single fraction, (iv) rats fed with standard diet and administered intraperitoneally DMBA (20mg/kg), (v) rats fed with standard diet and administered DMBA and 6 gray radiotherapy, (vi) rats fed with standard rat diet and administered DMBA and supplemented apricot, (vii) rats fed with standard diet supplemented apricot administered DMBA and radiotherapy (RT) for 6weeks. Expression of Bax, caspase 3, and glutathione activity decreased in the liver but liver expression of NF-κB, AP-1, CREB, Bcl-2 and ALT, AST, 5'NT, MDA, NO levels increased in DMBA-induced liver damage rats.

Effects of verapamil, nifedipine, and daflon on the viability of reverse-flow island flaps in rats.

Reverse-flow flaps are preferable in reconstructive surgery due to their several advantages. However, they may have venous insufficiency and poor blood flow. In this study, effects of various pharmacological agents on the viability of reverse-flow flaps were investigated.

Protective effects of resveratrol on salivary gland damage induced by total body irradiation in rats.

Objectives/hypothesis: One of the most common acute side effects of irradiation is xerostomia, which results from damage to the salivary gland cells by direct ionization. Resveratrol is a natural compound with profound anti-inflammatory and antioxidant properties. The purpose of the present study was to investigate the potential protective effects of resveratrol on injury to the salivary glands of rats that were exposed to total body irradiation.

Acute and chronic effects of electroconvulsive treatment on oxidative parameters in schizophrenia patients.

Electroconvulsive therapy (ECT) is an effective treatment alternative for schizophrenia. Previous studies have already indicated the possible effects of oxidative stress in this disorder. However, there have been no previous studies evaluating the effects of ECT on the oxidative stress in these patients.

Asymmetric dimethylarginine level in hyperglycemic gestation.

We aimed to evaluate plasma asymmetric dimethylarginine (ADMA) concentrations and its relation with insulin sensitivity/resistance indices in pregnant women with different degrees of carbohydrate intolerance. This study included a two step approach; 50 g glucose challenge test (GCT) followed by 100 g oral glucose tolerance test (OGTT) was used for diagnosis of carbohydrate intolerance within 24-28th weeks of gestation. Pregnant women with positive GCT but negative OGTT (AGCT group, n=30) and gestational diabetics (GDM group, n=58) were compared to healthy pregnant controls (n=50).

Evaluation of asymmetric dimethylarginine, nitric oxide levels and associated independent variables in obese and lean patients with polycystic ovarian syndrome.

Objective: To evaluate the asymmetric dimethylarginine (ADMA) and nitric oxide (NO) levels in obese and lean patients with polycystic ovarian syndrome (PCOS) and find out their relation with hormonal and metabolic parameters.

Methods: Twenty-two obese, 18 lean patients with PCOS and 11 obese, 24 lean healthy control patients were enrolled prospectively. Plasma ADMA and NO levels and arginine/ADMA ratio were evaluated on 3rd day of menstrual cycle after at least 10 h overnight fasting.

Vitreous vascular endothelial growth factor level during gestation.

Purpose: To evaluate the vitreous VEGF level alterations and its correlation with its plasma level if any, in gestation.

Methods: The blood and vitreous sampling procedures were performed before, during (20-23 days of gestation), and after gestation (2 months after birth) from seven White New Zealand rabbits. Blood samples were centrifuged then supernatants and vitreous samples were stored at -80 degrees C until assay.

Oral L-arginine protects against cyclosporine-induced hepatotoxicity in rats.

Cyclosporine A (CyA) leads to liver injury, probably by causing the production of free radicals and resulting in nitric oxide (NO) deficiency. We evaluated CyA-mediated liver damage histopathologically to determine the possible beneficial effects of L-arginine (L-Arg). In this study, 7 groups of Sprague-Dawley rats; (1) Control group; (2) 0.

Glutathione and malondialdehyde levels in patients with hydatid cyst.

Objective: To investigate the levels of glutathione (GSH), and malondialdehide (MDA) in the sera of patients diagnosed with cyst hydatid.

Methods: Forty-six hydatid cyst patients who were indirect hemaglutination (IHA) and indirect fluorescence antibody (IFA) test positive constituted our study group in 2007. Patients diagnosed with hydatid cyst in the Inonu University School of Medicine, Department of Parasitology were re-called for the study.

Activity of adenosine deaminase in mothers who have conceived a fetus with central nervous system malformations.

Objective: To establish the adenosine deaminase (ADA) activity in women who had been pregnant with a child suffering from central nervous system (CNS) anomaly.

Methods: The study group comprised 68 women who had been pregnant with an affected child, and 68 controls matched for age, gestational age and body mass index. Maternal venous blood was collected for measurement of ADA levels.

Do sodium channel blockers have neuroprotective effect after onset of ischemic insult?

Objective: Cerebral ischemia causes a series of pathophysiologic events that may result in cerebral infarct. Some neurons are more vulnerable to ischemia, particularly pyramidal neurons in the hippocampal CA1 region. Pharmacologic intervention for treatment of cerebral ischemia aims to counteract secondary neurotoxic events or to interrupt the progression of this process.

Serum amyloid A levels are increased in pre-eclampsia.

Aim: The purpose of this study was to examine serum amyloid A (SAA) levels in normal pregnant and pre-eclamptic women.

Methods: SAA levels were measured in 25 normotensive and 25 pre-eclamptic pregnant women by enzyme linked immuno-sorbent assay.

Results: In pre-eclampsia, SAA level and C-reactive protein (CRP) averaged 28.

Increased adenosine deaminase in hydatidiform mole.

Background: The aim of the current study was to investigate levels of adenosine deaminase in plasma of patients with hydatidiform mole.

Methods: Plasma adenosine deaminase levels were determined in 17 women with normal pregnant course, in 17 women with hydatidiform mole, and in 17 non-pregnant healthy volunteers.

Results: Mean adenosine deaminase activity in the hydatidiform mole group was 121.

House dust-mites: effect on antioxidant enzyme activities.

Background: House dust-mites are potent allergens of the indoor environment and are common inhabitants of houses worldwide. Free radicals are constantly produced by cells, mostly as reactive oxygen species. Once produced, free radicals are removed by antioxidant defenses, including the enzymes SOD, GPx, and CAT.

Dust-mites: effect on lipid peroxidation.

Background: Dust-mites are present in our homes, feed on dead exfoliated skin and other organic material. It is also known that oxidative stress may lead to cellular damage that can be confirmed by markers of cellular disruption. Oxidative stress in various infective processes has been documented.

The effect of resveratrol on surgery-induced peritoneal adhesions in an experimental model.

Adhesion formation is a common cause of complications following surgery. The aim of this study was to investigate the effect of resveratrol on intra-abdominal adhesion prevention in a rat model. Twenty one Wistar-Albino rats weighing 200-250 g were assigned to three groups, of 7 rats each.