Calcium Mobilization and Inhibition of Akt Reduced the Binding of PEO-1 Cells to Fibronectin.

Objectives: To investigate the effects of intracellular calcium (Ca) mobilization, β-catenin and Akt signal pathways after the binding of metastatic ovarian cells to fibronectin.

Materials And Methods: The expression levels of α4β1 and αvβ6 integrin were determined using α4, β1, αv, and β6 antibodies using flow cytometry on PEO-1 cells. The effect of [Ca]i on cell adhesion capacity was investigated using RTCA after stimulating PEO-1 cells using thapsigargin and tunicamycin.

Apoptotic effects of ε-viniferin in combination with cis-platin in C6 cells.

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