Publications by authors named "Aysha Mubeen"
Article Synopsis
- The study investigates the occurrence of rete hyperplasia and hyaline globules in germ cell tumors, with a focus on their potential to mimic yolk sac tumors, noting a significant misdiagnosis risk over the years.
- Out of 348 evaluated orchiectomies, 30% showed rete hyperplasia and/or hyaline globules, often without any yolk sac tumor component, suggesting a complexity in tumor classifications.
- The findings highlight the importance of accurately identifying these histological features, as they may indicate underlying testicular obstruction due to the tumor, which is crucial for proper treatment decisions.
Mullerianosis is a term used to describe a pathologic entity comprised of at least 2 types of Mullerian-type epithelia (tubal, endocervical, or endometrial) at non-gynecologic sites. This is an uncommon occurrence in the urinary tract. To the best of our knowledge, only 3 instances of Mullerianosis involving the ureter have been reported.
View Article and Find Full Text PDFAims: Classification of renal neoplasms on small tissue biopsies is in increasing demand, and maintaining broad differential diagnostic considerations in this setting is necessary. When evaluating a renal or perirenal tumour biopsy with sarcomatoid morphology, together with sarcomatoid renal cell carcinoma and sarcomatoid urothelial carcinoma as top diagnostic considerations, it is vital to additionally consider the possibility of well-differentiated and de-differentiated liposarcoma.
Methods And Results: This study reports a series of 30 biopsy samples from sites in or around the kidney collected from four institutions in which the correct diagnosis was either well-differentiated or de-differentiated liposarcoma.
Objective: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine neoplasm that predominantly affects elderly and immunocompromised patients. Merkel cell polyoma virus (MCPyV) is clonally integrated into the majority of MCCs and has been linked to patient outcomes, playing a central role in the pathogenesis of the disease. We aimed to assess the utility of MCPyV immunohistochemistry (IHC) in the diagnosis of MCC in cytology cell block specimens and correlating with clinicopathologic features.
View Article and Find Full Text PDFThe (forkhead box L2) gene is located on chromosome 3 and encodes for forkhead box (FOX) family of transcription factors which play a critical role in various biological processes. Germline mutations have been identified in blepharophimosis/ptosis/epicanthus inversus syndrome. The somatic missense mutation in ( C134W) is now known to be the defining molecular feature of adult-type granulosa cell tumour of the ovary, present in over 90% of cases of this tumour type.
View Article and Find Full Text PDFUterine mesenchymal lesions demonstrate various underlying genomic alterations involving MED12 , JAZF1 , YWHAE , BCOR , and ALK genes, among others. Recent publications describe a subset of high-grade endometrial stromal sarcoma lesions harboring BCORL1 gene aberrations including JAZF1::BCORL1 . Herein, we present an unusual benign endomyometrial spindle cell lesion that defies classificatory efforts by demonstrating mixed histomorphologic and immunohistochemical features of endometrial stromal nodule, leiomyoma, and uterine inflammatory myofibroblastic tumor while harboring a JAZF1::BCORL1 .
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- Western high-fat diets (HFD) are linked to an increased risk of prostate cancer, with studies on genetically modified mice showing that HFD promotes inflammation and tumor growth.
- The gut microbiome's composition changes due to HFD, which affects the host's immune response; it was found that high levels of histamine and increased mast cells are associated with larger prostate tumors in HFD-fed mice.
- Treatment with fexofenadine, an antihistamine, reduced tumor growth by affecting immune cell types and signaling pathways, suggesting that targeting gut microbiota and histamine signaling might be potential strategies for managing HFD-related prostate cancer.
Article Synopsis
- Adult granulosa cell tumor (AGCT) is the most common type of sex cord-stromal tumor in the ovaries, making up about 1% of all ovarian tumors, and is known for late recurrences.
- A case study of a 65-year-old woman with hemodynamic shock and bowel obstruction revealed mostly high-grade epithelioid and spindle cells with necrosis, along with a small fraction resembling typical AGCT.
- Unique findings included high-grade transformation dominating the tumor and the challenge in pinpointing the origin, highlighting the importance of molecular analysis for accurate diagnosis in complex cases.
Papillary renal cell carcinoma (especially type 2) is a Pandora's box with many newly described renal cell carcinomas emerging from it as a result of enhanced molecular techniques. Biphasic hyalinizing psammomatous renal cell carcinoma (BHPRCC) is the latest addition, which was first described a few months ago. Here, we report a case of BHPRCC to supplement the very limited literature available about this entity, and to highlight the characteristic morphology as well as the recurring molecular alterations in the neurofibromatosis 2 gene.
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- Mullerian adenosarcoma is a rare type of malignant uterine tumor characterized by both benign and malignant cells, and it can follow a history of pelvic irradiation.
- The case discussed involves a 45-year-old woman who experienced post-menopausal bleeding and had a history of cervical cancer treatment, later diagnosed with adenosarcoma showing malignant features.
- The patient faced a recurrence of the cancer three months later and ultimately passed away, emphasizing the need for further understanding of the relationship between radiation therapy and the development of such tumors.
Purpose: Pathological examination of placenta is vital to understand the pathophysiology of adverse perinatal outcomes, prevention of recurring conditions in subsequent pregnancies and medico-legal risk assessment. The College of American Pathologists (CAP) has published a set of guidelines to help guide the submission of placentas to pathology. However, awareness and conformity to these guidelines are not well established and vary from one institution to the other.
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- Recent claims suggested that cystoisospora organisms were found in the gallbladder mucosa of healthy patients, but this was later disproven through advanced molecular and ultrastructural research.
- The text provides a summary of the events surrounding the initial false epidemic of pseudo-Cystoisospora, outlining how it started and concluded.
- It emphasizes the significant role of additional diagnostic techniques in confirming the identification of pathogens alongside traditional morphological methods.
Background: Venous invasion (VI) is not frequently evaluated on routine histologic examination of head and neck squamous cell carcinoma (HNSCC), and the prognostic significance is largely unknown. Studies have shown that extramural venous invasion is an adverse prognostic factor in colorectal carcinoma. To our knowledge, this is the first study evaluating the prognostic significance of venous invasion in node-negative (without clinical or pathologic evidence of lymph node involvement) HNSCC, utilizing the elastic stain.
View Article and Find Full Text PDFObjectives: There is recently reported increased prevalence of Isospora organisms in cholecystectomy specimens from immunocompetent patients, especially in acalculous cholecystectomies. We performed an ultrastructural and molecular evaluation of these specimens.
Methods: From 28 gallbladders with intraepithelial inclusions, two specimens with diffuse involvement of the gallbladder epithelium were analyzed by electron microscopy.
Article Synopsis
- - The 2012 guidelines recommend reflex HR-HPV testing for women aged 21 and older with atypical Pap smear results, while women aged 30-65 can have HR-HPV testing every 5 years if they have negative Pap tests.
- - A study at the University of Florida analyzed nearly 20,000 cervical cancer screenings from 2006 to 2014, revealing significant differences in HPV positivity and epithelial abnormalities based on race and age.
- - Results showed African American women and those aged 14-20 had the highest rates of HPV positivity, emphasizing the need for targeted screening strategies for these high-risk groups.
Lymphoproliferative disorders cause significant morbidity and mortality, either related to the disease itself or therapy complications. Some cases of lymphoma may have vague clinical presentation, especially in the absence of lymphadenopathy, and a clinical work up may not be conclusive. Our study focuses on autopsy cases of lymphoma patients, emphasizing clinically unsuspected cases.
View Article and Find Full Text PDFAlbumin, widely recognized as a highly sensitive and specific marker of hepatocellular carcinoma (HCC), is currently unavailable in the diagnostic laboratory because of the lack of a robust platform. In a prior study we detected albumin mRNA in the majority of intrahepatic cholangiocarcinomas using a novel branched chain RNA in situ hybridization (ISH) platform. We now explore the utility of albumin ISH as a marker of hepatocellular differentiation in HCCs, and compare its sensitivity with Hep Par 1 and Arginase-1.
View Article and Find Full Text PDFSchwannomas are benign nerve sheath tumors composed of Schwann cells, which normally produce the insulating myelin sheath covering the peripheral nerves. Common locations include the head, neck, mediastinum, and retroperitoneum. These tumors are usually asymptomatic until they become large and compress the surrounding tissues.
View Article and Find Full Text PDFObjective: To determine the role of intraoperative cytology (IOC) in the diagnostic evaluation of ovarian neoplasms.
Methods: The present study was conducted in the Department of Pathology, Jawaharlal Nehru Medical College, AMU, Aligarh, India, over a time span of 18 months. Depending on the consistency of the lesion, touch, scrape or crush techniques were used to prepare cytological smears.
Objective: It was our aim to study the role of sediment cytology in a diagnostic evaluation of ovarian neoplasm.
Methods: The present study was conducted in the Department of Pathology, Jawaharlal Nehru Medical College, AMU, Aligarh, India, over a span of 22 months. Cytological smears were prepared by centrifuging the sediment of fluid from the bottom of a container in which surgical specimens were received.
We report here a case of thymoma simultaneously associated with undifferentiated pleomorphic sarcoma. A 45-year-old male presented with axillary lump. Radiographic studies showed a mediastinal mass.
View Article and Find Full Text PDFDuplication of appendix is extremely rare anomaly. The reported incidence is 0.004-0.
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