Publications by authors named "Aysha M Gardner"
Microglia are implicated as primarily detrimental in pain models; however, they exist across a continuum of states that contribute to homeostasis or pathology depending on timing and context. To clarify the specific contribution of microglia to pain progression, we take advantage of a temporally controlled transgenic approach to transiently deplete microglia. Unexpectedly, we observe complete resolution of pain coinciding with microglial repopulation rather than depletion.
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- Orthopedic injuries can result from various incidents like car accidents or falls, leading to persistent pain and complex damage to bones, muscles, and nerves.
- The review focuses on understanding how these injuries affect different tissues, specifically using rodent models to study trauma effects on bones, muscles, and nerves.
- It covers methods for assessing healing in bones, muscle regeneration, and pain responses, while drawing comparisons to human conditions to guide treatment development.