Upregulation of the secretory pathway Ca/Mn-ATPase isoform 1 in LPS-stimulated microglia and its involvement in Mn-induced Golgi fragmentation.

Microglia play an important protective role in the healthy nervous tissue, being able to react to a variety of stimuli that induce different intracellular cascades for specific tasks. Ca signaling can modulate these pathways, and we recently reported that microglial functions depend on the endoplasmic reticulum as a Ca store, which involves the Ca transporter SERCA2b. Here, we investigated whether microglial functions may also rely on the Golgi, another intracellular Ca store that depends on the secretory pathway Ca/Mn-transport ATPase isoform 1 (SPCA1).