Publications by authors named "Aysha Gaur"
A series of novel indole based sulfonohydrazide derivatives (-) containing morpholine heterocyclic ring were synthesized through multistep chemical reactions. The target compounds (-) were prepared by the reaction of substituted phenyl sulfonylhydrazides (-) with morpholine derivative of indole 3-carboxaldehyde. All the target compounds were screened for their anticancer activity against the estrogen receptor-positive breast cancer line MCF-7 and triple-negative breast cancer cell line, MDA-MB-468.
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- Human African and American trypanosomiasis are deadly diseases caused by the Trypanosoma protozoans, leading to millions of deaths and ongoing suffering due to their neglected status.
- Existing treatments for these diseases face challenges in safety, effectiveness, and issues with parasite resistance, highlighting the need for new therapeutic options.
- This review discusses promising drug development strategies, including target-based approaches, screening methods, drug repurposing, and combination therapies, as well as investigates potential new compounds to enhance treatment efficacy and combat resistance.