A novel thienothiophene-based "dual-responsive" probe for rapid, selective and sensitive detection of hypochlorite.

Background: Hypochlorite/hypochlorous acid (ClO/HOCl) is a biologically crucial reactive oxygen species (ROS), produced in living organisms and has a critical role as an antimicrobial agent in the natural defense system. However, when ClO is produced excessively, it can lead to the oxidative damage of biomolecules, resulting in organ damage and various diseases. Therefore, it is imperative to have a straightforward, quick and reliable method for over watching the minimum amount of ClO in different environments.