Publications by authors named "Aysenur Akyildiz-Igdem"

Article Synopsis
  • * A study involving 223 bladder cancer cases found that higher-grade and higher-stage tumors had decreased E-cadherin and increased vimentin expressions, confirming the role of EMT, while galectin-3 levels were higher in early-stage (T1) high-grade tumors but dropped in later stages (T2).
  • * The results suggest that galectin-3 is potentially important in early tumor progression, highlighting it as a possible
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  • - The study compared the effectiveness of two methods for analyzing ThinPrep Pap tests: the manual method (TPMM) and the automated method (TPAM), highlighting the benefits and downsides of each approach.
  • - Results showed that TPAM significantly improved the detection rates for abnormal cell types (ASCUS, LSIL, HSIL) and had better accuracy compared to TPMM, while also saving about 30% in screening time.
  • - Although TPAM offered higher sensitivity, it also had a higher false positive rate and rejected many samples due to errors like air bubbles, suggesting that using TPAM alongside TPMM could reduce false positives.
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Objective: Polypropylene meshes are one of the most frequently used patches in inguinal hernia repairs. This material was proved to be not completely inert, and may cause inflammatory responses like foreign body reactions. One of the physical results of these inflammatory reactions against the mesh is mesh shrinkage which is responsible for recurrence and pain.

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Liquid foreign material injection has been used as an early medical intervention since the end of nineteenth century for the augmentation of body shape. Nowadays, these types of procedures have been abandoned by health professionals due to late onset of serious complications. However, it is still misused by some subcultures such as bodybuilders, passive homosexuals, transsexuals, and patients with mental illness.

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Background/aims: Gastrointestinal and pancreatic neuroendocrine tumors (GEPNETs) originate from the cells of the endocrine system. Their molecular genetic mechanism of development and progression is complex and remains largely unknown. The purpose of this study was to review the gastrointestinal and pancreatic neuroendocrine tumors and to evaluate p53, Ki-67 and CD 117 expressions with their clinicopathological correlations.

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Background/aims: Acute pancreatitis accounts for almost 250.000 hospital admissions annually in the United States. Most promising treatment approaches are preventive; however, little is known about the early factors initiating acute pancreatitis.

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Objectives: To determine whether erosive esophagitis (EO) worsens reflux signs and symptoms and affects pulmonary function test in asthma patients.

Methods: Sixty asthma patients with gastroesophageal and laryngopharyngeal reflux symptoms were included. Spirometry, reversibility test, esophagogastroscopy, laryngoscopy, and esophagogastroscopic biopsies were conducted.

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Objective. To determine the long-term histopathologic changes in nasal mucosa and the relationship between progression of the histopathologic changes and the duration without air current stimulation. Material and Method.

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  • The study focuses on the impact of ligating the left renal vein (LRV) and associated collateral veins in rats that have had one kidney removed (right-nephrectomized).
  • The research compares outcomes of ligating the LRV alone and with the adrenal or gonadal collaterals, revealing that excluding gonadal collateral leads to significantly higher mortality due to kidney damage.
  • The conclusion highlights that ligation of the LRV near the inferior vena cava is safer when the gonadal collateral is preserved, while ligating it with adrenal collateral is less harmful.
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Aims: Considering the implications that arose from several recent experimental studies using recombinant human erythropoietin in rodents, erythropoietin has been regarded as a pharmacological preconditioning agent. The purpose of the present study was to evaluate whether erythropoietin has a preconditioning effect against ischemia and reperfusion injury in the small intestine of the rat.

Main Methods: Intestinal ischemia was induced in male Wistar rats by clamping the superior mesenteric artery for 30 min, followed by reperfusion for 180 min.

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Background: In this experimental study we evaluated the pH and potassium changes of the peritoneal irrigation fluid in the early phase of mesenteric ischemia.

Methods: The Wistar albino rats were assigned randomly to 5 equal groups of 10 rats: sham operation, 30, 60, 120 and 180 minutes ischemia by arterial occlusion. We enregistred the ranges of pH and potassium in peritoneal irrigation fluid and serum pH.

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One of common pathophysiological states associated with central nervous system is chronic cerebral hypoperfusion (CH) that frequently occurs in conditions such as vascular dementia and Alzheimer's disease. Long term blockage of angiotensin II type 1 (AT(1)) receptor provides protection from ischemia induced injury of brain as well as reduction of cerebrovascular inflammation. Examining effect of the blockage on reduced glutathione (GSH), ascorbic acid (AA), and lipid peroxidation were of purpose in the present study.

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Growing number of studies implicate that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, have beneficial effects on ischemia/reperfusion injury that are unrelated to their cholesterol-lowering action. In the present study, we aimed to evaluate possible effects of atorvastatin on oxidative stress, neutrophil accumulation, and contractile response of terminal ileum segments in rats subjected to intestinal ischemia/reperfusion. Intestinal ischemia/reperfusion model was generated by clamping the superior mesenteric artery for 30 min followed by reperfusion for 3 h.

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Background: The effect of epidermal growth factor (EGF) on gastrojejunostomy (anastomosis), fascia, and skin wound healing in rats was investigated.

Methods: The animals (rats) were separated into two main groups. In the first group (control group n: 23), rats were fed on standard diet and tap water without administration of EGF.

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