Antigenotoxic and Life-Prolonging Effects of Flavoured Kombuchas on .

Research Background: Kombucha is a fermented beverage with several health benefits; however, to improve its antioxidant activity, new raw materials such as hop, madimak and hawthorn were included in the present study.

Experimental Approach: The somatic mutation and recombination test (SMART) was performed on the fruit fly () to evaluate the antigenotoxic potential of black tea-flavoured kombucha and three other flavours of kombuchas (hop, madimak and hawthorn) against HO- and KCrO-induced genotoxicity. Furthermore, a lifespan assay was performed to assess the effects of kombuchas on the longevity of the fruit fly.

In vivo assessment of the toxic impact of exposure to magnetic iron oxide nanoparticles (IONPs) using Drosophila melanogaster.

Iron oxide nanoparticles (IONPs) have useful properties, such as strong magnetism and compatibility with living organisms which is preferable for medical applications such as drug delivery and imaging. However, increasing use of these materials, especially in medicine, has raised concerns regarding potential risks to human health. In this study, IONPs were coated with silicon dioxide (SiO), citric acid (CA), and polyethylenimine (PEI) to enhance their dispersion and biocompatibility.

Alcohol-free synthesis, biological assessment, in vivo toxicological evaluation, and in silico analysis of novel silane quaternary ammonium compounds differing in structure and chain length as promising disinfectants.

Quaternary ammonium compounds (QACs) are commonly used as disinfectants for industrial, medical, and residential applications. However, adverse health outcomes have been reported. Therefore, biocompatible disinfectants must be developed to reduce these adverse effects.

Morphologically different hydroxyapatite nanoparticles exert differential genotoxic effects in Drosophila.

Hydroxyapatite (HAP) occurs naturally in sedimentary and metamorphic rocks and constitutes the hard structures in many organisms. Since synthetic nano-sized HAP (HAP-NPs) are used in orthopedic applications and for heavy metal remediation in aquatic and terrestrial media, both environment and humans are exposed to them. Due to the concerns about their potential hazards, the genotoxic effects that round/rod forms of HAP-NPs were investigated in Drosophila using the wing-spot and the comet assays.

Comparative evaluation of natural and artificial sweeteners from DNA damage, oxidative stress, apoptosis, to development using .

The overconsumption of added sugars makes people vulnerable to a myriad of diseases. Several biochemical and developmental assays were performed in the current study to assess the effect of fructose on and to find substitutes for fructose by comparing it to well-known sweeteners. was exposed separately to the same ratio of sugar 9.

Computational assessment of the biological response of curcumin to type 2 diabetes mellitus induced by metal exposure.

The current study aimed to identify the molecular mechanisms of a metal mixture (cadmium, nickel, and lead) involved in type 2 diabetes mellitus (T2DM) development and the therapeutic effect of curcumin in this metal mixture-induced T2DM. To accomplish this, SwissADME assessed the physicochemical and pharmacokinetic properties of curcumin and the Prediction of Activity Spectra for Substances evaluates its biological activities. The Comparative Toxicogenomics Database, Cytoscape, AutoDock Vina, and MicroRNA ENrichment TURned NETwork were used as tools to perform data-mining approaches and molecular docking.