The first one-pot procedure for the double copper(I)-catalyzed oxidative Csp -H azidation-CuAAC process, implying unstable azide intermediates and easy-to-remove reagents under water-tolerant conditions, is presented. The combination of tert-butyl hydroperoxide as oxidant and TMSN as azide source for the C-H bond azidation, which produces harmless side-products such as tBuOH and H O, probed to be perfectly compatible with the following cycloaddition step. Highly demanding 1,2,3-triazoles could be then directly obtained in good overall yields by extraction or simple crystallization, thus avoiding chromatography purifications.
View Article and Find Full Text PDFJ Neurol Surg A Cent Eur Neurosurg
March 2016
Background: To achieve maximal resection with minimal risk of postoperative neurologic morbidity, different neurosurgical adjuncts are being used during low-grade glioma (LGG) surgery.
Objectives: To investigate the effect of pre- and intraoperative adjuncts on the extent of resection (EOR) of hemispheric LGGs.
Methods: Medical records were reviewed to identify patients of any sex, ≥ 18 years of age, who underwent LGG surgery at X Hospital between January 2005 and July 2013.
Background: Intraoperative magnetic resonance imaging (IoMRI) was devised to overcome brain shifts during craniotomies. Yet, the acceptance of IoMRI is limited.
Objective: To evaluate impact of IoMRI on intracranial glioma resection outcome including overall patient survival.
Background: In this study, we aimed to determine behaviors of women over 40 years toward methods of breast cancer early detection in a rural region of Ankara, Turkey.
Methods: Of the 1277 women aged over 40 years, 910 (71.3%) participated in the study.
Objective: Spontaneously occurring epidural hematoma without any identified etiology is a rare phenomenon. These are often neurosurgical emergencies; therefore, prompt diagnosis and treatment are paramount. Because of the rarity of this condition, we illustrated its presentation, evaluation and management in this recent case.
View Article and Find Full Text PDFBackground: Several prospective epidemiological studies have demonstrated that high-sensitivity C-reactive protein (hsCRP) and plasma homocysteine (hcy) are predictors of future coronary events among healthy men and women. The aim of the present study was therefore to investigate a possible relationship between hsCRP, hcy levels and body mass index (BMI), relative weight (RW), serum leptin levels, and cardiovascular risk factors in obese children and adolescents.
Methods: The study involved 28 obese children and adolescents (13 girls, 15 boys; BMI>95 per thousand for age and sex), 4.
Background: The significant roles of telomerase in carcinogenesis and drug resistance have attracted growing attention as potential therapies. The aim of the study was to investigate the effect of suramin on the telomerase activity of C6 glioma cells and on the growth of C6 glioma spheroids.
Material/methods: C6 rat glioma cells were treated with suramin at doses of 175 and 250 microM, and also with an increasing dosage for 96 hours.
Rat C6 glioma is a chemo-resistant experimental brain tumor that is difficult to treat with various drug combinations. Previous studies suggested that imatinib mesylate (Gleevec) is effective in pre-clinical trials for glioblastoma. Also, chlorimipramine (Anafranil) is an anti-depressant drug in use in the clinic and shown to have anti-neoplastic activity.
View Article and Find Full Text PDFPurpose: To perform an audit of our routine mammographic practice and to compare our results to performance benchmarks.
Materials And Methods: We analyzed the outcomes of 7,506 consecutive examinations performed in 1 year. Screening and diagnostic cases were evaluated separately and mammographic assessments were based on the Breast Imaging Reporting and Data System (BI-RADS) classification.
Purpose: The aim of this article was to investigate the efficacy of ultrasonography-guided core needle biopsy and prognostic factor analysis of breast cancer to plan overall treatment strategy.
Patients And Methods: A consecutive series of nonpalpable and palpable breast cancers constituted our study group (n= 201 lesions; mean size, 20.4 mm) Mean number of core samples was 3.
Diagn Interv Radiol
September 2007
Purpose: To investigate the factors affecting the mammographic breast dose.
Materials And Methods: The assessment was done on 622 qualified mammograms obtained with use of "variable kV" technique, i. e.
Diagn Interv Radiol
September 2007
Purpose: To evaluate in detail the ways and methods of mammography education, to survey currently used mammography devices, and to determine the quality of mammography examinations in Turkey in order to increase the quality of said examinations and to offer guidance to standardization studies in Turkey.
Materials And Methods: This study depended on the analysis of a questionnaire that was completed by volunteering medical centers. The questionnaire was mailed to all institutions in Turkey with a mammography device and which were registered with the Turkish Atomic Energy Commission and individual city health administration databases (n = 456).
Background: Training on breast health is required to increase awareness of early detection of breast cancer, especially in countries with limited resources.
Methods: Of the 784 invited women, 462 participated in the study (58.9%).
Basic Clin Pharmacol Toxicol
May 2007
The aim of the study was to determine bone mineral density changes caused by consumption of cola drinks and the associated factors. Thirty Sprague-Dawley rats were divided into four groups. Groups 1 and 2, consisting of 10 male and 10 female rats, respectively, were provided with as much food, water and cola drinks as they wanted.
View Article and Find Full Text PDFObjective: Our aim was to determine whether serum Insulin-like growth factor-I (IGF-I) and Insulin-like growth factor binding protein-1 (IGFBP-1) levels were different between type 2 diabetic patients and non-diabetic control group. We also aimed to establish any relationship that might exist between the serum IGF-I and IGFBP-1 levels with the urinary albumin excretion (UAE), creatinine clearance and urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion (as a marker of renal tubular dysfunction) and other parameters (such as age, duration of diabetes, treatment, etc.) in patients with type 2 diabetes mellitus (DM).
View Article and Find Full Text PDFAim: To compare BMD values of lumbar and hip regions measured in two different DXA scanners in one laboratory, and to investigate the efficiencies of implemented and specifically derived standardization formulas.
Materials And Methods: PA lumbar (L2-L4) and right femoral neck BMD values were obtained in 100 women (aged 26-75), consecutively in GE-Lunar DPX-NT and Hologic QDR 4500 C DXA scanners. Standardization of BMD values obtained in two different DXA devices was done according to the method developed by International DXA Standardization Committee (IDSC), using the European Spine Phantom (ESP) to obtain the specific constant value.
Interdigitating dendritic cell tumor (IDCT) is an extremely rare malignancy. It occurs primarily in lymph nodes, but extranodal involvement has also been reported. A 38-year-old woman with IDCT with breast and cervical lymph-node involvement is reported in this paper.
View Article and Find Full Text PDFPurpose: To evaluate and compare the usefulness of gray-scale and color-power Doppler sonography in differentiating benign from malignant axillary lymph nodes, and to find out whether the combined usage of both modalities increased the diagnostic accuracy.
Materials And Methods: Sixty lymph nodes in 59 patients were evaluated by gray-scale and color-power Doppler sonography. Color-power Doppler evaluation was based on the morphological patterns of vascularity.