Publications by authors named "Aysegul Burcin Yildirim"
Article Synopsis
- The study aimed to examine the protective effects of Thymoquinone (THQ) against testicular damage induced by Methotrexate (MTX) in rats.
- The experiment involved five groups and included sperm analysis, histopathology, and biochemical tests to assess the impact on testicular health.
- Results showed that THQ significantly improved sperm quality and testicular function parameters, indicating its potential role in mitigating infertility caused by chemotherapy.
Therapeutic use of fisetin and pirfenidone combination in bleomycin-induced pulmonary fibrosis in adult male albino rats.
Naunyn Schmiedebergs Arch Pharmacol
February 2025
Pulmonary fibrosis is an important health problem; one of the drugs used in its treatment is pirfenidone (PFD). Fisetin (FST) is a flavonoid with antioxidative, anti-inflammatory, and antifibrotic effects. The aim of this study was to induce PF in rats with bleomycin (BLM) and to investigate the combined effect of PFD and FST in the treatment of fibrosis.
View Article and Find Full Text PDFEffect of vitamin B12 on methotrexate-induced cardiotoxicity in rats.
Iran J Basic Med Sci
January 2024
Article Synopsis
- - This study investigates the cardiotoxic effects of methotrexate (MTX), a chemotherapy drug, and the potential protective role of vitamin B12 in mitigating this toxicity in rats.
- - Rats were divided into four groups: a control group, a vitamin B12 group, an MTX group, and a combined MTX and vitamin B12 group, with various biomarkers and tissue expressions evaluated to assess heart health.
- - The results showed MTX caused significant negative changes in heart-related factors and that vitamin B12 effectively normalized these changes, emphasizing the importance of vitamin B12 supplementation during MTX treatment.