Publications by authors named "Ayse Oktem"
Article Synopsis
- Single-cell RNA sequencing (scRNAseq) and flow cytometry in skin research are expensive and complex, often limiting their use for researchers, particularly when analyzing both RNA and protein from the same samples.* -
- The study introduces a new sample multiplexing strategy that allows for simultaneous scRNAseq and flow cytometry on paired blood and skin samples, enhancing data collection and analysis across healthy and inflamed specimens.* -
- This novel approach not only cuts costs by 2-4 times and reduces technical issues but also includes detailed protocols for implementation, making advanced skin analysis techniques more accessible for researchers.*
Background: Mycosis fungoides (MF) is the most common cutaneous lymphoma with a chronic disease course. MF patients may also suffer from systemic comorbidities such as cardiovascular and metabolic diseases.
Methods: In this study, we aimed to evaluate the demographic and clinical features of MF patients registered in the MF-TR registry system and to examine the relationship of these features with systemic comorbidities.
Article Synopsis
- The study aimed to investigate dermatological lesions linked with chronic itching (pruritus) in patients with type 1 and type 2 diabetes mellitus (DM) who visited a clinic.
- Out of 249 patients, 30.9% reported experiencing pruritus, and this group showed significantly higher rates of various complications like neuropathy and retinopathy compared to those without pruritus.
- Common skin issues found included xerosis (dry skin) and fungal infections, highlighting that chronic itching in diabetics may relate to poor health management and could warrant reevaluation of their medications.
Background: Pyoderma Gangrenosum (PG) is a chronic disease characterized by recalcitrant skin ulcers.
Objective: We aimed to evaluate the demographic, clinical characteristics, treatments and factors affecting the treatment responses of patients with PG.
Methods: We performed a multicenter study of 12 tertiary care centers.
Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome and telomere biology disorder, usullay consisting of a triad of oral leucoplakia, dystrophic nails, reticular skin pigmentation. The diagnosis in the majority of cases can be made following all the clinical findings of this triad are established. Here we report 7 years-old boy who had oral leukoplakia and nail abnormality without skin involvement, associated with bone marrow failure diagnosed with X-linked DC due to dyskerin (DKC1) mutation.
View Article and Find Full Text PDFBackground: Previous reports indicate that juvenile Behçet's disease (BD) may have a different course than adult BD. However, as a direct comparison with adult Behçet patients has only been made in a limited number of studies, the issue is still controversial.
Objectives: The primary aim of our study was to compare clinical manifestations in a large cohort of juvenile and adult Behçet patients registered in a single centre.
Introduction: Galectin-3 is a β-galactoside-binding lectin associated with cellular proliferation, inflammation and angiogenesis, which are the major characteristics of psoriatic skin.
Objectives: To investigate serum galectin-3 levels in psoriasis patients compared with healthy controls and to study its relationship with disease characteristics.
Methods: Seventy-eight patients diagnosed with psoriasis and 78 age- and sex-matched healthy volunteers were included in the study.
Background: Alopecia areata (AA) is an autoimmune disease where autoimmune dysregulations along with genetic susceptibility are hypothesized to play a role in pathogenesis.
Objective: The aim of this study in to evaluate HLA-A, HLA-B, HLA-C, HLA-DQB1, and HLA-DRB1 profile and its relationship with clinical features in AA patients.
Materials And Methods: Ninety-eight patients with AA and 100 healthy controls were included in the study.
Background: Palmoplantar pustulosis is a chronic and relapsing disease of the palms and soles, which is characterized by scattered clusters of pinhead-sized, sterile pustules.
Objective: The aim of the present study was to determine demographic features, co-morbidities, and relation of palmoplantar pustulosis with psoriasis.
Methods: A total of 48 patients (M/F: 15/33) were enrolled in the present study.
Background: Rosacea may result in emotional distress and anxiety. However, data on the presence of generalized anxiety disorder in rosacea patients are scarce.
Objective: The aim of the study was to detect the frequency and level of anxiety and depression in patients with rosacea.
Acne Vulgaris is a chronic inflammatory disease that requires long-term treatment. Adherence to treatment is a problem in chronic diseases and may affect treatment outcomes. We aim to investigate treatment adherence and satisfaction of patients with acne and identify independent factors that affect them.
View Article and Find Full Text PDFBackground/aim: Erythema nodosum (EN) is an inflammatory disorder of subcutaneous tissue. Although etiopathogenesis of the disease is unknown, many predisposing factors such as infections, systemic disease, and drugs have been identified. Neutrophil to lymphocyte ratio (NLR) has been shown to be a novel inflammatory marker in many dermatological diseases.
View Article and Find Full Text PDFDespite extensive usage of systemic isotretinoin in patients with acne for many years, laboratory monitoring protocols for adverse effects depend on the centers and there is no standardized practice for frequency and type of laboratory testing. We aimed to decrease unnecessary monitoring and to standardize our general clinical practice of our department as well as to provide patient comfort and cost saving. The medical charts of 704 acne patients treated with systemic isotretinoin were reviewed retrospectively.
View Article and Find Full Text PDFBackground: Alopecia areata (AA) is an autoimmune-mediated hair follicle disorder. In the literature, there is no study evaluating metabolic syndrome and levels of ischemia-modified albumin (IMA) which is proposed as an oxidative stress biomarker in patients with AA.
Aims: The aim was to investigate the presence of metabolic syndrome and the levels of IMA, small dense low-density lipoprotein (sd-LDL), and visfatin levels in AA patients.
According to the "desmoglein compensation theory," anti-Dsg1 and anti-Dsg3 profiles are crucial for the clinical outcome of pemphigus vulgaris. However, recent studies have highlighted several cases with an incompatibility between the antibody profile and clinical manifestation. Data of 37 patients who had been diagnosed pemphigus vulgaris in our Department between January 2014-June 2016 were retrieved from our clinical database.
View Article and Find Full Text PDFBackground: Management of chronic urticaria (CU) is often difficult with oral antihistamines (OAs) despite long-term use.
Objective: The aim of this study was to determine the extent of medication compliance (MC) and to assess the factors affecting the MC of patients with CU toward OA therapy.
Methods: A 43-item questionnaire was administered to 201 adult patients.
Background: Epidermolysis bullosa acquisita (EBA) is a rare subepidermal bullous disease. Long-term remission in this disease is difficult using current treatments, unlike that in patients with other autoimmune bullous diseases.
Objective: We retrospectively evaluated the effectiveness and side effects of rituximab-intravenous immunoglobulin (IVIg) combination treatment in five patients with EBA resistant to conventional treatment.
Objective: Evaluation of the efficacy and side effects of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser and Nd:YAG laser-intense pulsed light (IPL) combination treatments in photorejuvenations of skin of the hand, and determining their impacts on patient satisfaction.
Materials And Methods: Thirty-five female patients with signs of photoaging on the skin of their hands were included in the study. Three sessions of IPL and four sessions of Nd:YAG laser treatment were applied to the right hand in total with 2-week intervals between each session, whereas six sessions of Nd:YAG laser treatment were applied to the left hand of patients with 2-week intervals between each session.