A study on the possible neurotoxic effects of CUMYL-4CN-BINACA in Sprague Dawley rats.

Substances such as Δ9-tetrahydrocannabinol (THC) and cannabidiol cross the blood-brain barrier. Detecting the damage of these substances in the brain provides important data in drug abuse studies. The aim of the study is to define the neurotoxicity of a novel synthetic cannabinoid (CUMYL-4CN-BINACA) in the Sprague-Dawley rats.

Diurnal variation of anterior segment parameters handled with Scheimpflug imaging in keratoconus patients.

Purpose: To define diurnal changes in anterior segment parameters of keratoconus patients by using Scheimpflug imaging.

Methods: All keratoconus patients had corneal topography measurements 3 times a day (around 09:00 AM, 13:00 PM and 17:00 PM) by the same experienced operator. Three consecutive scans in each measurement session were obtained.

The assessment of choroidal thickness with spectral-domain optical coherence tomography during Valsalva maneuver.

Purpose: The purpose of the study was to evaluate the effect of Valsalva maneuver (VM) on choroidal thickness.

Methods: All the volunteers underwent a detailed opthalmic examination. Third-generation Spectralis OCT device (software version 5.