Enzyme-Based Antiviral Potential of J. Presl. Essential Oil and Its Major Component ()-Cinnamaldehyde.

In the present study, J. Presl. bark essential oil and its main component cinnamaldehyde was evaluated for neuraminidase (NA), transmembrane serine protease (TMPRSS2), and angiotensin converting enzyme 2 (ACE2) inhibitory activities.

Comparative In Vitro and In Silico Enzyme Inhibitory Screening of and Essential Oils and Geraniol.

The present work aims to evaluate Herrm. and L'Hér. essential oils, and the major constituent geraniol for their in vitro and in silico inhibitory activities against -lipoxygenase (5-LOX), cyclooxygenase (COX), acetyl cholinesterase (AChE), butyryl cholinesterase (BuChE), and angiotensin converting enzyme (ACE2) enzymes.

Anti-Inflammatory and Anticancer Evaluation of L. and L. Essential Oils.

Spearmint, L., and the German chamomile, L., preparations are used against inflammatory conditions traditionally and in modern medicinal applications.

Wound Healing Activity of .

Objective: In this study, the antioxidant properties of plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of fruits. This study aimed to assess and determine the possible pharmacological activities of and evaluate its potential to act as a wound care plant.

Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in Vitro and in Silico Approaches.

Arum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain, arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study investigated the antioxidant properties, individual phenolic compounds, total phenolic and total flavonoid contents (HPLC/MS analysis), reducing power and metal chelating effects of four extracts obtained from A. elongatum (ethyl acetate (EA), methanol (MeOH), methanol/water (MeOH/water) and infusion).

In Vitro Antiviral Evaluations of Coldmix: An Essential Oil Blend against SARS-CoV-2.

Coldmix is a commercially available and, blend for medicinal applications. In this present study, the in vitro antiviral potential of Coldmix, and its major constituents 1,8-cineole and α-pinene were evaluated by using the in vitro ACE2 enzyme inhibition assay as well as the direct contact test against SARS-CoV-2. The observed ACE2 enzyme inhibitory activity of Coldmix, 1,8-cineole, and α-pinene were 72%, 88%, and 80%, respectively; whereas in the direct contact test in the vapor phase, the destruction of the virus was 79.

ACE2 and LOX Enzyme Inhibitions of Different Lavender Essential Oils and Major Components Linalool and Camphor.

In this present study, , , and essential oils and their main compounds linalool and camphor were evaluated for lipoxygenase enzyme (LOX) and for angiotensin converting enzyme 2 (ACE2) inhibition potential. The chemical compositions of , , and essential oils were confirmed both by gas chromatography-mass spectrometry and gas chromatography-flame ionization detection, where 22.4, 0.

Binary Synergistic Combinations of Lavender and Fennel Essential Oils with Amoxicillin.

Microbial resistance is an important problem in modern healthcare systems. In addition to drug resistance, the side effects of current antibiotic applications are also known issues. In this present study, binary combinations of amoxicillin with European Pharmacopoeia quality lavender () and fennel () essential oils were evaluated against human pathogenic microbial strains.

In Vitro and In Silico Evaluation of ACE2 and LOX Inhibitory Activity of Origanum Essential Oils and Carvacrol.

spp. are used both for culinary purposes and for their biological activities. In this study, commercial , and essential oils and their prominent constituent carvacrol were evaluated for their and angiotensin-converting enzyme 2 and lipoxygenase enzyme inhibitory potentials.

Phytochemical Compounds Loaded to Nanocarriers as Potential Therapeutic Substances for Alzheimer's Disease-Could They be Effective?

Alzheimer's disease accounts for a high percentage of dementia cases in elderly individuals. This type of brain disease is caused by damage to the brain cells affecting the ability of the patients to communicate, as well as their thinking, behavior, and feelings. Although numerous research laboratories focus on advancements in treating Alzheimer's disease, the currently approved pharmacological approaches seem to only alleviate the symptoms.

Anti-inflammatory, analgesic and in vivo-in vitro wound healing potential of the Phlomis rigida Labill. extract.

Ethnopharmacological Relevance: The preparations of Phlomis aerial parts are used traditionally in Anatolia for wound healing and in inflammatory disorders.

Methods: For the identification of the active fraction, the air dried aerial parts of Phlomis rigida Labill. were extracted by methanol and fractionated successively by n-hexane, dichloromethane and ethyl acetate, respectively.

In Vivo Wound Healing and In Vitro Anti-Inflammatory Activity Evaluation of Extract Gel Formulations.

The air-dried aerial parts of (Sims) Lag. Ex Benth. was extracted by methanol and fractionated by -hexane, dichloromethane, and ethyl acetate, respectively.

Opuntia ficus indica Fruits Ameliorate Cisplatin-Induced Nephrotoxicity in Mice.

This study aims to determine the potential renal protective effects of Opuntia ficus-indica (L.) Miller (OFI) fruits against cisplatin-induced nephrotoxicity in mice. The antioxidant activity of OFI methanol extract was calculated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) free radical scavenging assays.

An Alternative Approach Wound Healing Field with Polypodium Vulgare.

Objective: In this study, we examined the effects of Polypodium vulgare L. (Polypodiaceae) as a candidate to be used for wound healing scarred area. We investigated the antibacterial, and antioxidant activity of P.

Design and synthesis of novel cylopentapyrazoles bearing 1,2,3-thiadiazole moiety as potent antifungal agents.

In drug-resistant phytopathogenic fungi, there has been extensive research on microbiological and antifungal drug development. In this study, a novel series of cylopentapyrazole bearing a 1,2,3-thiadiazole ring 2a-e were designed and synthesized according to the principle of combination of bioactive structures. Thus, we have employed a [3 + 2] cycloaddition with 4-methyl-[1,2,3] thiadiazole-5-carboxylic acid hydrazones 1a-e and cyclopentadiene ring.

Antioxidant Activity of Blackthorn (Prunus spinosa L.) Fruit Extract and Cytotoxic Effects on Various Cancer Cell Lines.

Objective: Blackthorn (Prunus spinosa L. (Rosaceae) is a shrup whose fruits are consumed as food in Turkey. This study was aimed to evaluate antioxidant activity of methanol extract of P.