Publications by authors named "Aysın Tulunay Virlan"
Article Synopsis
- - Psoriatic arthritis (PsA) affects about 150,000 individuals in the UK, with half requiring biologic treatments that target TNF or IL-17A, though predicting patient response remains challenging, leading to trial and error in treatment.
- - A new study aims to see if measuring specific immune cell types (Th17 levels) in patients can help predict which biologic treatment (TNF inhibitors or IL-17A inhibitors) will work best for them, potentially speeding up the treatment response.
- - Participants will be divided into two groups based on their Th17 levels and receive either TNF (adalimumab) or IL-17A (secukinumab) treatments; the study will evaluate treatment effectiveness
Aim: The study aimed to evaluate the differentiation ability of intravitreally injected rat bone marrow-derived mesenchymal stem cells (rBM-MSCs) to retinal ganglion-like cells in a polystyrene microsphere induced rat glaucoma model.
Materials And Methods: The glaucoma rat model was generated via intracameral injection of 7 microliter polystyrene microspheres. Green fluorescence protein-labeled (GFP) rBM-MSCs were transplanted intravitreally at or after induction of ocular hypertension (OHT), depending on the groups.
Background: Nesfatin-1 (NES-1), an anorexigenic peptide, was reported to have anti-inflammatory and anti-apoptotic actions in several inflammation models.
Methods: To elucidate potential renoprotective effects of NES-1, unilateral ureteral obstruction (UUO) was induced in male Sprague Dawley rats by ligating left ureters. The rats were injected intraperitoneally with either saline (SL) or NES-1 (10 µg/kg/day) for 7 or 14 days (n = 8 in each group).
Annexin-A1 has a well-defined anti-inflammatory role in the innate immune system, but its function in adaptive immunity remains controversial. This glucocorticoid-induced protein has been implicated in a range of inflammatory conditions and cancers, as well as being found to be overexpressed on the T cells of patients with autoimmune disease. Moreover, the formyl peptide family of receptors, through which annexin-A1 primarily signals, has also been implicated in these diseases.
View Article and Find Full Text PDFOne hundred eighty-seven healthy and unrelated volunteers from various regions of Turkey were selected for the study. Killer-cell immunoglobulin-like receptors (KIR) genotyping was performed by polymerase chain reaction using commercial sequence-specific oligonucleotide probe (SSOP) kits. Gene frequencies of the Turkish population were determined by direct counting of the positive and negative loci.
View Article and Find Full Text PDFObjectives: Interleukin-17 (IL-17) has been associated with the pathogenesis of various autoimmune/inflammatory diseases. The aim of this study was to investigate the expression of Th17-related immunity in an innate immunity-dominated vasculitis, namely Behcet's disease (BD).
Methods: Peripheral blood mononuclear cells from 37 patients (age: 38.