Publications by authors named "Ayrolles A"

Article Synopsis
  • Early-onset restrictive eating disorders (rEO-ED), including early-onset anorexia nervosa (EO-AN) and avoidant restrictive food intake disorders (ARFID), have unknown impacts on brain development.
  • A study comparing brain features through MRI in children under 13 with EO-AN, ARFID, and typically developing peers revealed differing brain structures despite similar BMI, indicating unique brain mechanisms for each disorder.
  • Findings suggest EO-AN is linked to thinner cortex structures, while ARFID patients showed reduced surface area and subcortical volume, highlighting the need for further research on the relationship between low BMI and neurodevelopmental impacts in eating disorders.
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Background: Anorexia nervosa (AN) is a serious multifactorial eating disorder characterized by insufficient nutritional intake to maintain a minimum normal weight for one's age and height, a fear of gaining weight and a distorted body image. It affects mainly adolescents, but a decreased age at diagnosis has been reported, leading to the definition of a rare form of AN called early-onset or prepubertal anorexia nervosa (EOAN; ORPHA 525738), with reported epidemiological and clinical specificity. Current knowledge and specific treatments for this particular condition remain scarce.

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Autism Spectrum Disorder (ASD) is defined by distinctive socio-cognitive behaviors that deviate from typical patterns. Notably, social imitation skills appear to be particularly impacted, manifesting early on in development. This paper compared the behavior and inter-brain dynamics of dyads made up of two typically developing (TD) participants with mixed dyads made up of ASD and TD participants during social imitation tasks.

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The two most frequent early-onset restrictive food intake disorders are early-onset anorexia nervosa (EOAN) and avoidant/restrictive food intake disorders (ARFID). Although the core symptoms of EOAN (i.e.

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Background: In children with early-onset anorexia nervosa (first symptoms before 13 years old, EO-AN), experts recommend initial outpatient treatment but in-patient treatment (IP) is frequently indicated due to acute medical instability or for those who have not improved with outpatient treatment. This IP can target either a partial weight restauration or a total weight normalization (return to the previous BMI growth trajectory). There are no evidence in the literature on which is the better therapeutic option in EOAN.

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Objective: Early-onset anorexia nervosa (EO-AN) is characterized by restricted food intake leading to low body weight, emerging before 14 years old. Most patients reaching a target body mass index (BMI) around the 25th percentile at hospitalization discharge display an incomplete prospective height catch-up. A better understanding of height prognosis determinants is required.

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Article Synopsis
  • This study investigated how genetic factors (specifically, polygenic risk scores for schizophrenia) interact with psychosocial stressors (like childhood trauma and discrimination) to influence the risk of subclinical psychosis in individuals without diagnosed psychotic disorders.* -
  • Researchers analyzed data from the EU-GEI study, which included European descendants, focusing on different dimensions of subclinical psychosis measured by the CAPE scale, and used various statistical models to explore these associations.* -
  • The findings revealed no significant gene-environment interactions; however, the polygenic risk score was linked to positive psychosis dimensions, while psychosocial stressors negatively impacted all subclinical dimensions.*
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Aims: Since the beginning of the COVID pandemic, studies reported an increase in children's mental health issues and questioned the impact of SARS-CoV-2 on psychiatric symptoms.

Methods: We compared COVID seroconversion in children hospitalized with acute, severe psychiatric symptoms (n = 52) with the sex- and age-matched control group (n = 52) living in the same low-income geographic area and sampled during the same time period.

Results: Contrary to our hypothesis, we observed less seroconverted children with psychiatric conditions 9.

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The bulk of social neuroscience takes a 'stimulus-brain' approach, typically comparing brain responses to different types of social stimuli, but most of the time in the absence of direct social interaction. Over the last two decades, a growing number of researchers have adopted a 'brain-to-brain' approach, exploring similarities between brain patterns across participants as a novel way to gain insight into the social brain. This methodological shift has facilitated the introduction of naturalistic social stimuli into the study design (e.

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Background: The Paris and Nice terrorist attacks affected a thousand of trauma victims and first-line responders. Because there were concerns that this might represent the first of several attacks, there was a need to quickly enhance the local capacities to treat a large number of individuals suffering from trauma-related disorders. Since Reconsolidation Therapy (RT) is brief, relatively easy to learn, well tolerated and effective, it appeared as the ideal first-line treatment to teach to clinicians in this context.

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Unlabelled: Body dysmorphic disorder (BDD) is characterized by excessive preoccupation with a slight or imagined defect in one's physical appearance, believing they look ugly, abnormal or deformed. While the most common preoccupations focus on the skin, hair and nose, any part of the body may be involved. Preoccupations are intrusive, time-consuming and hard to control.

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