Investigation of pregnancy tendency, reproductive characteristics, and disability in women with multiple sclerosis: A secondary data analysis of the national registry in Iran.

Multiple sclerosis (MS) predominantly affects women of childbearing age, significantly impacting their quality of life (QOL). The diagnosis of MS can influence pregnancy intention, and the level of disability associated with MS may change before and after pregnancy. This study aims to analyze the reproductive characteristics of Iranian female patients with MS (PwMS) and their association with the Expanded Disability Status Scale (EDSS) and pregnancy tendency, providing valuable insights into disease progression and the development of tailored treatments.

Novel spirooxindole-triazole derivatives: unveiling [3+2] cycloaddition reactivity through molecular electron density theory and investigating their potential cytotoxicity against HepG2 and MDA-MB-231 cell lines.

A novel analogue of hybrid spirooxindoles was synthesized employing a systematic multistep synthetic approach. The synthetic protocol was designed to obtain a series of spirooxindole derivatives incorporating triazolyl--triazine framework via [3 + 2] cycloaddition (32CA) reaction of azomethine ylide ( with the corresponding chalcones . Unexpectedly, the reaction underwent an alternate route, leading to the cleavage of the s-triazine moiety and yielding a series of spirooxindole derivatives incorporating a triazole motif.

Prevalence and Temporal Trends of Multidrug-resistant Tuberculosis in Iran from 1981 to 2023: A Systematic Review and Meta-analysis.

Background: Multidrug-resistant tuberculosis (MDR-TB) is a serious threat to global tuberculosis (TB) control efforts. This study aims to investigate the trend of MDR-TB prevalence in Iran over 20 years.

Methods: A systematic literature search was conducted in various databases, including PubMed, Embase, and Web of Science, from 1981 to 2023.

Estimating the copepod biomass in the North West African upwelling system using a bi-frequency acoustic approach.

The Canary Current Large Marine Ecosystem (CCLME) is one of the most productive Large Marine Ecosystems worldwide. Assessing the abundance, biomass and distribution of zooplankton in the southern part of this system, off the coast of West Africa, remains challenging due to limited sampling efforts and data availability. However, zooplankton is of primary importance for pelagic ecosystem functioning.

Integrating proximal soil sensing data and environmental variables to enhance the prediction accuracy for soil salinity and sodicity in a region of Xinjiang Province, China.

Soil salinization and sodification, the primary causes of land degradation and desertification in arid and semi-arid regions, demand effective monitoring for sustainable land management. This study explores the utility of partial least square (PLS) latent variables (LVs) derived from visible and near-infrared (Vis-NIR) spectroscopy, combined with remote sensing (RS) and auxiliary variables, to predict electrical conductivity (EC) and sodium absorption ratio (SAR) in northern Xinjiang, China. Using 90 soil samples from the Karamay district, machine learning models (Random Forest, Support Vector Regression, Cubist) were tested in four scenarios.

Climate change impacts on small pelagic fish distribution in Northwest Africa: trends, shifts, and risk for food security.

Climate change is recognised to lead to spatial shifts in the distribution of small pelagic fish, likely by altering their environmental optima. Fish supply along the Northwest African coast is significant at both socio-economic and cultural levels. Evaluating the impacts of climatic change on small pelagic fish is a challenge and of serious concern in the context of shared stock management.

The Role of Efflux Pumps transporter in Multi-drug Resistant Tuberculosis: Mycobacterial memberane protein(MmpL5).

Background: The overexpression of efflux pumps (Eps) was reported to contribute to multidrug resistant tuberculosis (MDR-TB). Increases in Eps that expel structurally unrelated drugs contribute to reduced susceptibility by decreasing the intracellular concentration of antibiotics. In the present study, an association of mycobacterial membrane protein (MmpS5-MmpL5) Ep and its gene regulator (Rv0678) was investigated in MDR-tuberculosis isolates.

New Functionalized Di-substituent Imidazolium Ionic Liquids as Superior Faster Absorbents for Carbon Dioxide Gas.

Functionalization of room temperature liquids based on disubstituted imidazolium ionic liquids represents a promising avenue for tailoring their tunable physicochemical properties and expanding their potential application as green solvents to capture carbon dioxide as a greenhouse gas. In this work, new hydroxyl functionalized imidazolium ionic liquids were prepared from condensation of ethanolamine with glyoxal and formalin in the presence of acetic acid as catalyst. The chemical modification of the hydroxyl groups with epichlorohydrine added new hydroxylpropanoxychloride groups on the imidazolium cation that were quaternized with -methylimidazolium chloride to produce new imidazolium acetate ionic liquids.

Economic and Social Standing of Individuals in Iran Diagnosed with Multiple Sclerosis.

Background: Multiple sclerosis (MS) may be affected by socioeconomic status (SES). This study aims to explore the determinants of SES among Iranian patients with MS and examine how these factors relate to disability and disease progression.

Methods: All patients with MS listed in the nationwide MS registry of Iran (NMSRI) until January 8, 2022, were included in this population-based study.

Pine needles as bioindicator and biomagnetic indicator of selected metals in the street dust, a case study from southeastern Iran.

Among the different approaches currently being used to evaluate the contamination level of street dust, the magnetic susceptibility of dust and urban tree leaves has received little attention. The key objectives of this study were: (i) to investigate the feasibility of using pine needles as a bioindicator and biomagnetic indicator for estimating the concentration of selected metals in street dust, and (ii) to predict the contamination level of street dust by selected metals using magnetic susceptibility. Street dust and pine tree needle samples were taken from 60 locations in three adjacent cities in Kerman province (Kerman, Rafsanjan, and Sirjan), southeastern Iran.

Digital exploration of selected heavy metals using Random Forest and a set of environmental covariates at the watershed scale.

The current study was established for predicting some selected heavy metals (HMs) including Zn, Mn, Fe, Co, Cr, Ni, and Cu, by applying random forest (RF) and a set of environmental covariates at watershed scale. The objectives were to find out the most effective combination of variables and controlling factors on the variability of HMs in a semiarid watershed in central Iran. One hundred locations were selected in the given watershed in the hypercube manner and soil samples from a surface 0-20 cm depth and concentration of HMs and some soil properties were measured in the laboratory.

The National Multiple Sclerosis Registry System of Iran (NMSRI): aspects and methodological dimensions.

Introduction: Multiple Sclerosis (MS) as one of the most common causes of disability around the world requires a uniform standardized information registry system to help policy-makers systematically plan for care quality improvements. The aim of this study is to verify aspects and methodological scopes of MS registry system in Iran.

Methods: The National MS Registry System in Iran (NMSRI) is a population-based registry system that systemically identifies and collects all MS patients' data in a specific geographical area.

Corrigendum: Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors.

[This corrects the article DOI: 10.3389/fchem.2022.

Magnetic susceptibility as a proxy for detection of total petroleum hydrocarbons in contaminated wetlands.

Soil petroleum hydrocarbon contamination in the wetlands could cause ecological risk, especially through leakage into water reservoirs. So, the detection of the spatial variability of total petroleum hydrocarbons (TPH) in these soils is very crucial. The variability of TPH and its associations with magnetic susceptibility (χ) in contaminated soils around the Shadegan pond in southern Iran was investigated.

Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors.

A series of pyrazolyl--triazine compounds with an indole motif was designed, synthesized, and evaluated for anticancer activity targeting dual EGFR and CDK-2 inhibitors. The compounds were tested for cytotoxicity using the MTT assay. Compounds , , and showed promising cytotoxic activity against two cancer cell lines, namely A549, MCF-7, and HDFs (non-cancerous human dermal fibroblasts).

Natural Clay Minerals as Potential Arsenic Sorbents from Contaminated Groundwater: Equilibrium and Kinetic Studies.

Arsenic (As) contaminated groundwater is a worldwide concern due to its chronic effects on human health. The objectives of the study were to evaluate natural inexpensive raw laterite (RL) and kaolinite (RK) for their potential use as As sorbents and to understand the As sorption on laterite and kaolinite by employing sorption and kinetic models. Raw laterite and RK were tested for EC, pH, XRF and CEC as basic parameters.

Parenting Styles Predict Future-Oriented Cognition in Children: A Cross-Sectional Study.

Parenting is a crucial environmental factor in children's social and cognitive development. This study investigated the association between parenting styles and future-oriented cognition skills in elementary school-aged children. Cross-sectional data were collected from parents of 200 Iranian elementary school aged children (6-13 years), 139 boys and 61 girls.

Comparison of Different Machine Learning Methods for Predicting Cation Exchange Capacity Using Environmental and Remote Sensing Data.

This study was conducted to examine the capability of topographic features and remote sensing data in combination with other auxiliary environmental variables (geology and geomorphology) to predict CEC by using different machine learning models ((random forest (RF), k-nearest neighbors (kNNs), Cubist model (Cu), and support vector machines (SVMs)) in the west of Iran. Accordingly, the collection of ninety-seven soil samples was performed from the surface layer (0-20 cm), and a number of soil properties and X-ray analyses, as well as CEC, were determined in the laboratory. The X-ray analysis showed that the clay types as the main dominant factor on CEC varied from illite to smectite.

Clinical nutrition approach in medical management of COVID-19 hospitalized patients: A narrative review.

Background: Malnutrition in COVID-19 hospitalized patients is associated with a high-risk condition to increase disease severity and prolonging the recovery period. Therefore, nutritional therapy, including supplements plays a critical role to reduce disease-related complications and the length of hospital stay.

Aim: To review the latest evidence on nutritional management options in COVID-19 hospitalized patients, as well as possibly prescribed supplements.