Publications by authors named "Ayoub Sabri"
Increased prevalence of latent tuberculosis infection (LTBI) has been observed among high-risk populations such as healthcare workers (HCWs). The results may depend on the method of LTBI assessment, interferon-gamma release assay (IGRA) and/or tuberculin skin test (TST). Here, we investigated the prevalence and risk factors for LTBI assessed by both IGRAs and TST in HCWs living in Morocco, a country with intermediate tuberculosis (TB) endemicity and high BCG vaccination coverage.
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- Autosomal recessive TYK2 deficiency can lead to increased susceptibility to bacterial and viral infections, with varying symptoms among affected individuals.
- Eight patients from different ethnicities were studied, revealing that while they all faced infections due to impaired immune responses, none exhibited the full hyper-IgE syndrome features seen in the first patient described.
- The core issue in TYK2 deficiency is the inability to effectively respond to certain interleukins (IL-12 and IFN-α/β), which causes the infections, but the lack of HIES symptoms suggests that impaired IL-6 responses are not a fundamental aspect of this deficiency.
Background: Only a minority of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis. Genetic epidemiological evidence suggests that pulmonary tuberculosis has a strong human genetic component. Previous genetic findings in Mendelian predisposition to more severe mycobacterial infections, including by M.
View Article and Find Full Text PDFOnly a small fraction of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB) in their lifetime. Genetic epidemiological evidence suggests a genetic determinism of pulmonary TB (PTB), but the molecular basis of genetic predisposition to PTB remains largely unknown. We used a positional-cloning approach to carry out ultrafine linkage-disequilibrium mapping of a previously identified susceptibility locus in chromosomal region 8q12-13 by genotyping 3,216 SNPs in a family-based Moroccan sample including 286 offspring with PTB.
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