Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity.

Chemotherapeutic drugs and radiotherapy are fundamental treatments to combat cancer, but, often, the doses in these treatments are restricted by their non-selective toxicities, which affect healthy tissues surrounding tumors. On the other hand, drug resistance is recognized as the main cause of chemotherapeutic treatment failure. Rosmarinic acid (RA) is a polyphenol of the phenylpropanoid family that is widely distributed in plants and vegetables, including medicinal aromatic herbs, consumption of which has demonstrated beneficial activities as antioxidants and anti-inflammatories and reduced the risks of cancers.

Bl. seeds as a new source of bioactive compounds with promising antioxidant and antimicrobial properties.

The fruits of Bl. (Elaeocarpaceae) are edible and are normally prescribed for treatment of diseases. The medicinal uses of the fruit create considerable quantities of seeds as wastes.

Chemical constituents from the leaves of .

The genus belongs to the Elaeocarpaceae family, consists of about 350 species distributed in the tropical and subtropical regions. Plants in the genus, reportedly, contain compounds known for various biological activities like affinity for the δ-opioid receptor, antioxidant, cytotoxicity and antimicrobial activities. , commonly known in India as 'Indian Olive' is a medicinal plant widely distributed through Eastern Asia and the pacific.