A sensitive, rapid and cost-effective RP-HPLC-UV method for detection and quantification of bedaquiline in physiological fluid (pH 7.4).

Bedaquiline, a highly lipophilic molecule, is used in the treatment regimen of multi-drug resistant tuberculosis. A rare complication of pulmonary tuberculosis is tuberculous pericarditis. studies utilising animal pericardium can be used to investigate whether this drug is capable of diffusing across pericardial tissue into simulated pericardial fluid (pH 7.

Performance, HSP70 expression, antioxidant enzymes, oxidative DNA damage biomarkers, metabolic hormones, and intestinal microbiota of broiler chickens fed mistletoe leaf powder supplemented diets under tropical high ambient temperatures.

The study investigated the impact of Mistletoe Leaf Powder (MLP) supplementation on some parameters in heat-stressed broiler chickens. The standard baseline diets, comprising four different formulations, were provided during the starter and finisher stages. Chickens were randomly assigned to the 4 dietary groups: a negative control (CON) with no supplementation, a positive control (VTC) with 200 mg/kg vitamin C, and 2 experimental treatment groups with 2500 mg/kg (MLP2) and 5000 mg/kg (MLP5) MLP supplementation.

Dietary supplementation of Capsicum powder affects the growth, immunoglobulins, pro-inflammatory cytokines, adipokines, meat, and liver histology of aflatoxin B1 exposed broiler chickens.

The effects of dietary supplementation with Capsicum annuum fruit pericarp powder (CPP) and Capsicum annuum fruit seed powder (CSP) on the health and performance of broiler chickens exposed to aflatoxin B1 (AFB1) was investigated. Four dietary groups were established: CON (control), AFT (0.5 mg/kg AFB1), CPAF (0.

Nutraceutical Effects of Leaf Powder Supplementations on Performance, Blood Indices, Heat Shock Protein 70, Oxidative Deoxyribonucleic Acid Damage Biomarkers and Intestinal Microbes of Broiler Chickens, Under Tropical Condition.

The main reason preventing broiler chickens from reaching their genetic potential and hurting their performance in the tropics is heat stress. This study aimed to ascertain how leaf powder (JLP) supplementation affects broiler chickens' performance, blood indices, antioxidant status, and gut microflora in tropical environments. A completely randomized method was used to assign 240 Cobb 500 broiler chicks to the experimental diets (6 replicates per diet, 10 birds per replication).

Herbal inclusions ameliorate effect of heat stress on haematology, proinflammatory cytokines, adipokines and oxidative stress of weaned rabbit does in humid tropics.

A study was designed to evaluate the effect of Moringa oleifera, Phyllanthus amarus and Viscum album leaf meal as herbal inclusions to alleviate the detrimental outcomes of heat stress in weaned female rabbits. Forty (40) weaned rabbit does (527.99 ± 10.

Advances in immunomodulatory strategies for host-directed therapies in combating tuberculosis.

Tuberculosis (TB) maintains its infamous status regarding its detrimental effect on global health, causing the highest mortality by a single infectious agent. The presence of resistance and immune compromising disease favours the disease in maintaining its footing in the health care burden despite various anti-TB drugs used to fight it. Main factors contributing to resistance and difficulty in treating disease include prolonged treatment duration (at least 6 months) and severe toxicity, which further leads to patient non-compliance, and thus a ripple effect leading to therapeutic non-efficacy.

The Cost of Setting Up an ENT Endoscopic Practice in Lower Middle-Income Countries of Sub-Saharan Africa.

Ear, nose, and throat (ENT) surgeons in developing countries are constrained to practicing with lower technology, lower cost surgery, and reliance on outdated surgical techniques carried out with improvised instruments when compared with their counterparts in the developed world. In this review, we planned to lay open the bottle necks militating against setting up an ENT endoscopy practice in our setting with possible outcomes. The literature search was carried out to retrieve relevant published articles, books, and guidelines.

COVID-19: Challenges and coping strategies in radiology departments in Nigeria.

Context: COVID-19 came suddenly, bringing to the fore the challenges inherent in the health system. In a developing country, such as Nigeria, which already had myriad problems with funds and equipment in the health sector.

Aims: This study aims to examine the challenges encountered by the staff in Radiology facilities and how they combated the challenges.

Clinical evaluation and nasoendoscopic scores of patients with chronic rhinosinusitis in Ilorin, Nigeria.

Introduction: chronic rhinosinusitis (CRS) is characterised by inflammation of the mucosal lining of the nose and paranasal sinuses for at least 12 weeks duration. Other than the diagnostic criteria that is based on clinical features; nasoendoscopy and/or computerized tomographic scan have been included in the diagnosis. This study seeks to outline the clinical evaluation and nasoendoscopic assessment of CRS patients.

Potential of watermelon () to maintain oxidative stability of rooster semen for artificial insemination.

Fruits with antioxidant enrichment can be an economically affordable supplement for mitigating oxidative damage prone spermatozoa membrane pathologies. Computer-assisted sperm analyzer and oxidative status were utilized to evaluate the impact of watermelon () fortification of dextrose saline as diluent for rooster semen and fertility response of hens inseminated. Watermelon juice and dextrose saline were used to formulate diluent of 7 treatments consisting of unextended semen (positive control), 10%, 20%, 30%, 40%, 50% and only dextrose saline (negative control) designated as Treatments 1-7.

Diagnostic accuracy of flexible fiberoptic laryngoscopy: experience from a tertiary health institution in Nigeria.

Background: Flexible fibreoptic laryngoscopy (FFL) is a technique of laryngeal visualization. The instrument (flexible laryngoscope) is relatively scarce in resource challenged countries. Where available, it is a useful compliment to the armamentarium of clinical tools at the disposal of the otolaryngologist.

Oxidative status and spermatozoa kinetics of rooster semen in citrus juice-based diluent.

Poultry spermatozoa are prone to oxidative damage and adversely affect their fertility. Bioactive constituents of citrus fruit confer antioxidant enrichment on its juice and are candidates to combat oxidative load in poultry semen. Computer-assisted semen analyser and oxidative status were used to evaluate the potency of two tropical citrus varieties (sweet orange and tangerine) as natural diluents for rooster semen.

Normative references and clinical correlates of fetal umbilical artery Doppler indices in southwestern Nigeria.

Objective: To derive normative references for umbilical artery (UA) Doppler indices, including pulsatility index (PI), resistance index (RI), and systolic/diastolic (SD) ratio, for singleton pregnancies in Ile-Ife, Nigeria, and compare them with reference values from other populations.

Methods: A longitudinal study involving 415 women with a singleton fetus at 26-40 gestational weeks attending Obafemi Awolowo University Hospital, Ile-Ife, between July 2015 and March 2019. Fetal UA PI, RI, and SD ratio were measured every 4 weeks until delivery.

Neem, pawpaw and bamboo leaf meal dietary supplementation in broiler chickens: Effect on performance and health status.

The effect of the diet supplemented with leaf meals (LM) of neem (NLM), pawpaw (PLM), bamboo (BLM) and their composite leaf mix (CLM) on broiler chickens was assessed. Three hundred 1-day old broiler chickens were distributed to five diets: (control/no LM), (5 g/kg NLM), (5 g/kg PLM), (5 g/kg BLM) and (5 g/kg NLM+PLM+BLM 1:1:1). Body weight gain of birds fed BLM and CLM supplemented diets were similar but higher (p < 0.

Protective effect of soursop ( linn.) juice on oxidative stress in heat stressed rabbits.

Background: Preventing oxidative stress in heat stressed animals may be possible by increasing antioxidant defence via exogenous administration of antioxidant substrate and/or its precursors. The study aimed to investigate the effect of Soursop juice in mitigating oxidative stress induced by heat stress in rabbit.

Methods: Sixty mixed breed rabbit bucks aged 12-18 months old with the average weight of 1826 ± 8.

Gliricidia leaf meal and multi-enzyme in rabbits diet: effect on performance, blood indices, serum metabolites and antioxidant status.

Background: Following the ban on the importation of import-dependent fed ingredients in most developing countries, the need to look inward for local content is now compelling. Thus, leaf meals that have phytogenic additive potentials are envisaged will be a viable feed ingredient in rabbit diets.

Methods: The effect of dietary inclusion of gliricidia leaf meal (GLM) with or without multi-enzyme (E) supplementation in rabbits was investigated using ninety-six 35-day old rabbits of crossbreed (Newzealand and Chinchilla).

Trends and complications of ear piercing among selected Nigerian population.

Background: The reported health and socioeconomic consequences of ear piercing, especially in modern day society, underscore the need to further research into this subject. In this study, we determine the trends and complications of ear piercing among selected Nigerian population.

Aim And Objectives: The aim and objective of this study was to draw attention to the trends and complications of ear piercing with a view to prevent its associated complications.

Indications and outcome of tracheostomy in Ilorin, North Central Nigeria: 10 years review.

Background: The study aims to highlight common indications as well as outcome of treatment among patients with tracheostomy in Ilorin, North-Central Nigeria.

Methods: A review of clinical records of all patients with tracheostomy over a period of ten years (2002-2011), using the Theatre, Ward, ICU and the emergency register after approval from the ethical review committee. Data retrieved included; demographic profile, primary diagnosis, indication for tracheostomy, surgical technique, hospital admission and care outcome of management.

Clinical Presentation and Outcome of Sinonasal Tumors in a Nigerian Tertiary Hospital - 6-year Review.

Background: Sinonasal tumor is an uncommon tumor in Nigeria, but the burden of the disease in terms of morbidity and mortality is on the increase. The aim of this study is to evaluate the pattern of presentation and outcome of sinonasal tumor in our center.

Methodology: This was a retrospective review of all the patients with sinonasal cancer seen in Ear, Nose, and Throat Department of the hospital between January 2008 and December 2013.

Management and Outcome of Rhinosinusitis in Nigeria.

Objective: The aim of this study is to present the management and outcome of treatment of rhinosinusitis in Nigeria.

Study Design: A retrospective review of the case notes of patients with rhinosinusitis between January 2009 and December 2014.

Setting: Study at the University of Ilorin Teaching Hospital, Nigeria, using retrieved case notes after ethical approval was received.

Shear-flow-controlled mode selection in a nonlinear autocatalytic medium.

The effect of shear flow on mode selection and the length scale of patterns formed in a nonlinear autocatalytic reaction-diffusion model is investigated. We predict analytically the existence of transverse and longitudinal modes. The type of the selected mode strongly depends on the difference in the flow rates of the participating species, quantified by the differential flow parameter.

Lattice Boltzmann study of pattern formation in reaction-diffusion systems.

Pattern formation in reaction-diffusion systems is of great importance in surface micropatterning [Grzybowski et al., Soft Matter 1, 114 (2005)], self-organization of cellular micro-organisms [Schulz et al., Annu.

Effect of aspect ratio on transverse diffusive broadening: a lattice Boltzmann study.

We study scaling laws characterizing the interdiffusive zone between two miscible fluids flowing side by side in a Y-shape laminar micromixer using the lattice Boltzmann method. The lattice Boltzmann method solves the coupled three-dimensional (3D) hydrodynamics and mass transfer equations and incorporates intrinsic features of 3D flows related to this problem. We observe the different power-law regimes occurring at the center of the channel and close to the top/bottom wall.