Publications by authors named "Ayodeji O Oladele"

The majority (85%) of nonsyndromic cleft lip with or without cleft palate (nsCL/P) cases occur sporadically, suggesting a role for de novo mutations (DNMs) in the etiology of nsCL/P. To identify high impact protein-altering DNMs that contribute to the risk of nsCL/P, we conducted whole-genome sequencing (WGS) analyses in 130 African case-parent trios (affected probands and unaffected parents). We identified 162 high confidence protein-altering DNMs some of which are based on available evidence, contribute to the risk of nsCL/P.

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Background: A scar can be defined as a mark or a blemish resulting from a healed wound. All surgical incisions give rise to scars and approximately 15% have excessive scars. Some scars are thin lines which are almost unnoticeable, whereas others become abnormal when the amount of fibrosis is excessive or suboptimal or when it causes functional disability or aesthetic distress to the patient.

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Introduction: Chronic wounds (CWs) are a common problem around the world. Although known to affect quality of life, patients' perception may vary among cultures.

Objective: The purpose of this article is to determine the effects of CWs on health-related quality of life (HRQoL) and identify wound care practices among a select population in southwestern Nigeria.

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Article Synopsis
  • Orofacial clefts, including cleft palate only (CPO) and cleft lip with or without palate (CL/P), are prevalent developmental disorders that create various clinical and psychological challenges.
  • In a study involving around 17 million genetic markers among sub-Saharan African populations, researchers identified new genetic loci associated with CPO on chromosomes 2 and 19, suggesting potential biological mechanisms.
  • The study confirmed the significance of previously known loci such as 8q24 for CL/P, along with the replication of other established genes like PAX7 and VAX1, contributing to our understanding of these conditions.
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Background: Wounds are commonly encountered in the clinical practice. Microbacterial colonization and infection negatively affect wound outcomes. With increasing emergence of antibiotic-resistant strains, it is essential to determine local patterns of wound microbiological profile and antibiotic susceptibility to guide rational empirical antibiotic use.

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Objective: To present management challenges, surgical technique, and outcome associated with penoscrotal reconstruction in patients with giant scrotal lymphedema in sub-Saharan Africa.

Methods: A prospective study of all patients who had penoscrotal reconstruction for giant scrotal lymphedema at our university teaching hospital between January 2003 and December 2012 was carried out. Patients' preoperative clinical evaluation findings, operative technique, and postoperative course were reviewed after obtaining ethical approval and informed consent from the patients.

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Objective: To determine the knowledge and cultural beliefs about the etiology and management of orofacial clefts in Nigeria's major ethnic groups.

Design: Questionnaires designed to elicit respondents' knowledge and cultural beliefs about the etiology and management of orofacial clefts.

Setting: Northern and southern Nigerian communities where the major ethnic groups reside.

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