Unravelling the Influence of Chlorogenic Acid on the Antioxidant Phytochemistry of Avocado ( Mill.) Fruit Peel.

Oxidative stress is pivotal in the pathology of many diseases. This study investigated the antioxidant phytochemistry of avocado ( Mill.) peel.

Ferulic acid interventions ameliorate NDEA-CCl-induced hepatocellular carcinoma via Nrf2 and p53 upregulation and Akt/PKB-NF-κB-TNF-α pathway downregulation in male Wistar rats.

Hepatocellular carcinoma is a prevalent form of liver cancer that is life threatening. Many chemically synthesized anti-cancer drugs have various degrees of side effects. Hence, this study investigated the effect of FEAC interventions on NDEA-CCl-induced HCAR in male Wistar rats.

Reversal of mitochondrial permeability transition pore and pancreas degeneration by chloroform fraction of (L.) leaf extract in type 2 diabetic rat model.

Unmanaged Diabetes Mellitus (DM) usually results to tissue wastage because of mitochondrial dysfunction. Adverse effects of some drugs used in the management of DM necessitates the search for alternative therapy from plant origin with less or no side effects. (L.

The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases.

The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier separating the blood and the tissues in several organs. ECs maintain endothelium integrity by controlling the constriction and relaxation of the vasculature, blood fluidity, adhesion, and migration. These actions of ECs are efficiently coordinated via an intricate signaling network connecting receptors, and a wide range of cellular macromolecules.

Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches.

Prostate cancer is one of the malignancies that affects men and significantly contributes to increased mortality rates in men globally. Patients affected with prostate cancer present with either a localized or advanced disease. In this review, we aim to provide a holistic overview of prostate cancer, including the diagnosis of the disease, mutations leading to the onset and progression of the disease, and treatment options.

Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of in Wistar Rats.

Toxicities due to exposure to arsenic-contaminated water and the occurrence of diabetes mellitus are major health concerns. Treatment of these concerns using therapeutic measures have recorded limited success. Traditionally, (LA) has been used in managing various diseases.

Hepato-Genoprotective Activities of Methanol Extract of The Stem Bark of Adansonia Digitata LINN. In Wistar Rats Challenged with Sodium Arsenite.

Arsenic exposure is an issue of concern in developing countries, consequently leading to arsenicosis which has been implicated in the development of cancers. The stem bark of Adansonia digitata (SBAD) has many traditional medicinal uses. The aim of the present study was to assess the antigenotoxic and hepatoprotective effects of methanol extract of SBAD (MESBAD) against sodium arsenite - induced toxicities in Wistar rats.

A Common Insecticide Induced-Oxidative Stress in Wistar Rats: Significance for Humans and Implications for Nutritional Modulation of Insecticide Toxicity.

Objective: This study examined the levels of selected micronutrients and associated biochemical changes in rats exposed to Baygon® insecticide. Arsenic is a toxic metalloid commonly used in insecticides manufacture but unheralded.

Methods: Fifteen rats, divided into three equal groups: Group I (control); group II (administered 2.

Methanol Extract of Leaf Protects Against Sodium Arsenite-induced Toxicities in Male Wistar Rats.

Background: Human and animal population exposure to arsenic through the consumption of arsenic contaminated water is rampant in many parts of the world. Protective agents of medicinal plants origin could provide maximum protection against toxicities of various kinds.

Objective: The protective role of orally administered methanol extract of the leaves of (MELAD) on sodium arsenite (SA) - induced clastogenicity and hepatotoxicity in male Wistar rats was evaluated.

Modulatory role of Acacia honey from north-west Nigeria on sodium arsenite-induced clastogenicity and oxidative stress in male Wistar rats.

Effect of Acacia honey from north-west Nigeria on sodium arsenite-induced oxidative damage and clastogenicity in male Wistar rats was investigated. Animals were divided into four groups and were treated daily via oral gavage for one week before they were sacrificed. Brain, liver and blood serum were collected for antioxidant and protein assays.

Toxicity associated with repeated administration of artemether-lumefantrine in rats.

Chemotherapy remains an important approach in the fight against malaria. Artemether-lumefantrine combination is widely in use due to its effectiveness against Plasmodium falciparum. Misuse in the form of multiple repeated doses of this anti-malaria drug is rampant in Nigeria.