Haemo- and endoparasites of indigenous chickens reared in Gwagwalada Area Council, Abuja, Nigeria.

Poultry production as one of the major sources of protein in Nigeria is constrained by parasitic diseases including haemo- and gastrointestinal (GI) parasites. The haemo- and endoparasites of indigenous chickens reared in Gwagwalada market, Gwagwalada Area Council, Abuja, Nigeria were studied. Blood and fecal samples were collected from 108 chickens (Gallus gallus domesticus) between April–August, 2017.

Membrane-Bound Transcription Factor Site-1 Protease in PF429242 Bound State: Computational Kinetics and Dynamics of Reversible Binding.

Membrane-bound transcription factor site-1 protease (S1P) is an emerging clinical target due to its roles in lipogenesis, lysosomal biogenesis, unfolded protein response and viral glycoprotein processing. In this study, homology model of S1P was created in order to understand the structural basis for S1P inhibition by PF429242 using molecular docking, molecular dynamics simulation and in silico kinetics studies. PF429242 was docked (GlideScore=-5.

T-705-modified ssRNA in complex with Lassa virus nucleoprotein exhibits nucleotide splaying and increased water influx into the RNA-binding pocket.

Lassa virus infection is clinically characterized by multiorgan failure in humans. Without an FDA-approved vaccine, ribavirin is the frontline drug for the treatment but with attendant toxicities. 6-Fluoro-3-hydroxy-2-pyrazinecarboxamide (T-705) is an emerging alternative drug with proven anti-Lassa virus activity in experimental model.