Deciphering the host genetic factors conferring susceptibility to severe COVID-19 using exome sequencing.

The COVID-19 pandemic remains a significant public health concern despite the new vaccines and therapeutics. The clinical course of acute SARS-CoV-2 infection is highly variable and influenced by several factors related to the virus and the host. Numerous genetic studies, including candidate gene, exome, and genome sequencing studies, genome-wide association studies, and other omics efforts, have proposed various Mendelian and non-Mendelian associations with COVID-19 course.

Quantitative Electroencephalography Analysis for Improved Assessment of Consciousness Levels in Deep Coma Patients Using a Proposed Stimulus Stage.

"Coma" is defined as an inability to obey commands, to speak, or to open the eyes. So, a coma is a state of unarousable unconsciousness. In a clinical setting, the ability to respond to a command is often used to infer consciousness.

The Clinical and Laboratory Efficacy of HA 330 Treatment Combined with Continuous Renal Replacement Therapy in Septic Shock Patients: A Case Series.

Introduction: Blood purification therapy is a method used to enable cytokine removal and to improve disturbed immune homeostasis in patients with sepsis or septic shock. This study aimed to evaluate the impact of HA 330 treatment on biochemical and hemodynamic parameters and cytokine levels in adult patients with septic shock.

Methods: Critically ill patients with septic shock who received continuous veno-venous hemodiafiltration and HA 330 treatment were included in this prospective observational study.

New Avenues to Explore in SARS-CoV-2 Infection: Both TRIM25 and TRIM56 Positively Correlate with VEGF, GAS6, and sAXL in COVID-19 Patients.

The ongoing COVID-19 pandemic poses a significant threat to human health. Many hypotheses regarding pathogenesis have been proposed and are being tried to be clarified by experimental and clinical studies. This study aimed to reveal the roles of the innate immune system modulator GAS6/sAXL pathway, endothelial dysfunction markers vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1, and antiviral effective TRIM25 and TRIM56 proteins in pathogenesis of COVID-19.

Classification of Depth of Coma Using Complexity Measures and Nonlinear Features of Electroencephalogram Signals.

In recent years, some electrophysiological analysis methods of consciousness have been proposed. Most of these studies are based on visual interpretation or statistical analysis, and there is hardly any work classifying the level of consciousness in a deep coma. In this study, we perform an analysis of electroencephalography complexity measures by quantifying features efficiency in differentiating patients in different consciousness levels.

Analysis of Consciousness Level Using Galvanic Skin Response during Therapeutic Effect.

The neurological status of patients in the Intensive Care Units (ICU) is determined by the Glasgow Coma Scale (GCS). Patients in coma are thought to be unaware of what is happening around them. However, many studies show that the family plays an important role in the recovery of the patient and is a great emotional resource.