Publications by authors named "Aynaz Mohammadi"
Background: It is widely recognized that obesity is characterized by a chronic low-grade inflammatory condition. In the context of childhood and adolescent obesity, there is also a noteworthy correlation with elevated levels of inflammatory markers. These markers signify a proinflammatory state that may have relevance to the development of MS.
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- Multiple sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous system, with cognitive dysfunction present in at least 65% of patients, impacting various cognitive abilities.
- A systematic review and meta-analysis evaluated cognitive function in MS patients using the MACFIMS assessment tool, collecting data from eight studies involving 1,481 MS patients and 1,072 healthy controls.
- Results showed significant cognitive deficits in MS patients compared to healthy controls, particularly in processing speed and working memory, highlighting the importance of recognizing and assessing cognitive impairment in MS for better clinical outcomes.
Objective: Modic changes (MCs) in the cervical spine are common, but remain an under-researched phenomenon, particularly regarding their prevalence, natural history, risk factors, and implications for surgical outcomes. This systematic review and meta-analysis endeavors to elucidate the multifactorial dimensions and clinical significance of cervical MCs.
Methods: Following PRISMA guidelines, a comprehensive systematic search was performed using Medline (via PubMed), EMBASE, Scopus, and Web of Science databases from their dates of inceptions to September 4, 2023.
Key Clinical Message: This case highlights the challenges in diagnosing Bethlem myopathy, the need for a high index of suspicion, and the importance of recognizing the diverse clinical presentations of this rare condition. Enhanced understanding can aid in early diagnosis and tailored management.
Abstract: Bethlem myopathy (BM), a rare collagen VI-related myopathy, is characterized by progressive muscle weakness and contractures, typically affecting the proximal muscles and joints.
Background: The Neutrophil-to-Lymphocyte Ratio (NLR) is a clinical indicator of peripheral inflammation that is easily accessible. It is worth noting that the formation of amyloid-β (Aβ) plaques and neurofibrillary tangles has been linked to inflammation and immune dysregulation. The main objective of this systematic review and meta-analysis is to comprehensively evaluate the existing body of research concerning the NLR in the context of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
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- This study is a systematic review focusing on degenerative cervical myelopathy (DCM), which is a spinal cord disorder often requiring surgery, and investigates how diffusion tensor imaging (DTI) can differentiate DCM patients from healthy individuals.
- It includes 57 studies and shows that DTI parameters, such as fractional anisotropy (FA) and apparent diffusion coefficient (ADC), have distinct values in DCM patients compared to healthy controls.
- The findings indicate that while FA correlates with symptom severity, ADC could be useful for deciding treatment approaches for mild DCM cases, helping to determine which patients may need surgery versus conservative treatment.
This case report details a challenging instance of undifferentiated/unclassified cardiac sarcoma in a 28-year-old female, presenting with diverse symptoms like muscle weakness, shortness of breath, and hemoptysis. Diagnostic hurdles led to an initial misdiagnosis of granulomatosis with polyangiitis before discovering a sizable left atrial mass, ultimately diagnosed as high-grade undifferentiated/unclassified sarcoma. Despite initial surgical intervention, the patient's condition worsened, underscoring the complexities in managing such cases involving cardiac sarcomas.
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- This study is a systematic review investigating the link between pre-operative diffusion tensor imaging (DTI) metrics and post-operative outcomes in patients with degenerative cervical myelopathy (DCM).
- The review found that fractional anisotropy (FA) was significantly correlated with post-operative improvement, particularly in patients aged 65 and older, while the apparent diffusion coefficient (ADC) showed a relationship with recovery rate across all ages.
- Despite these findings, the authors concluded that more evidence is needed to confirm whether DTI metrics can reliably predict post-operative recovery, which could aid in selecting candidates for surgery.*
Coinfection of pulmonary mucormycosis and tuberculosis is a rare and challenging condition, particularly in immunocompromised patients. We present the case of a 60-year-old woman with poorly controlled diabetes mellitus who developed dysphonia, persistent cough, and expectoration. Imaging studies revealed a cavitary lesion and a mass in the left lung, along with stenosis of the left main bronchus.
View Article and Find Full Text PDFThe association between multiple sclerosis and migraine: A meta-analysis.
Mult Scler Relat Disord
November 2023
Background: Multiple sclerosis (MS) is a chronic progressive condition marked by the deterioration of myelin and impairment of neurological function. The global prevalence of MS is approximately 2.2 million.
View Article and Find Full Text PDFAlthough many frailty tools have been used to predict traumatic spinal injury (TSI) outcomes, identifying predictors of outcomes after TSI in the aged population is difficult. Frailty, age, and TSI association are interesting topics of discussion in geriatric literature. However, the association between these variables are yet to be clearly elucidated.
View Article and Find Full Text PDFFrailty is a known predictor of negative health outcomes. The role of frailty in predicting outcomes after traumatic brain injury (TBI), however, is unclear. This systematic review aimed to evaluate the association between frailty and adverse outcomes in patients with TBI.
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