Antiprotozoal screening of the Cuban native plant Scutellaria havanensis.

Context: Scutellaria havanensis Jacq. (Lamiaceae) is a native medicinal herb with a history of use in Cuba.

Objective: This study screens the antiprotozoal activity of S.

[In vivo antiplasmodial activity of Mycale laxissima and Clathria echinata sponges].

Introduction: the search of new antimalarial compounds comprises, among its challenges, the development of therapeutic alternatives for cerebral malaria; due to the high mortality and neurological deficiencies that persist after treatment with recommended drugs.

Objectives: to evaluate the activity of organic fractions of Mycale laxissima and Clathria echinata in the cerebral malaria model of infection of C57BL/6 mice with Plasmodium berghei ANKA.

Methods: preparative fractions of both species were obtained by reverse-phase flash chromatography.

In vitro antimalarial activity and cytotoxicity of some selected cuban medicinal plants.

Terrestrial plants have been demonstrated to be sources of antimalarial compounds. In Cuba, little is known about antimalarial potentials of plant species used as medicinals. For that reason, we evaluated the antimalarial activity of 14 plant species used in Cuba as antimalarial, antipyretic and/or antiparasitic.

Acridine and acridinones: old and new structures with antimalarial activity.

Since emergence of chloroquine-resistant Plasmodium falciparum and reports of parasite resistance to alternative drugs, there has been renewed interest in the antimalarial activity of acridines and their congeners, the acridinones. This article presents literature compilation of natural acridinone alkaloids and synthetic 9-substituted acridines, acridinediones, haloalcoxyacridinones and 10-N-substituted acridinones with antimalarial activity. The review also provides an outlook to antimalarial modes of action of some described compounds.

[Antimalarial activity of hydroalcoholic extract from Bixa orellana L].

Introduction: Bixa orellana L. is one species used in traditional herb medicine in several continents. Among the medicinal properties attributed to this plant, the antimalarial action has been included.

[Antimalarial activity and cytotoxicity of hydroalcoholic extracts from six plant species used in Cuban traditional medicine].

Introduction: Malaria is the most important parasitic disease for global health. Lack of the structural diversity in current antimalarials demands the urgent search for new therapeutic alternatives. The plants have shown their potential to provide effective antimalarials, therefore, a large sample of Cuban medicinal plants is being studied.

In vitro anti-microbial activity of the Cuban medicinal plants Simarouba glauca DC, Melaleuca leucadendron L and Artemisia absinthium L.

In the present study, an extensive in vitro antimicrobial profiling was performed for three medicinal plants grown in Cuba, namely Simarouba glauca, Melaleuca leucadendron and Artemisia absinthium. Ethanol extracts were tested for their antiprotozoal potential against Trypanosoma b. brucei, Trypanosoma cruzi, Leishmania infantum and Plasmodium falciparum.