Publications by authors named "Ayman M E M Sadek"
Article Synopsis
- Microscopic colitis (MC) is a significant but often overlooked cause of chronic diarrhea, especially when colonoscopy results appear normal, prompting the need for more thorough diagnostic methods.
- A study involving 116 patients showed that 32.8% were diagnosed with MC, with lymphocytic colitis being more prevalent, and elevated inflammatory markers like fecal calprotectin, ESR, and CRP were linked to MC.
- Symptoms such as nocturnal diarrhea and abdominal pain were strongly associated with MC, and specific cutoff values for inflammatory markers demonstrated high accuracy for diagnosis, indicating the necessity for further exploration and validation in future research.
Article Synopsis
- Mucormycosis has emerged as a serious fungal infection following COVID-19, raising concerns about mortality risk factors in affected patients.
- A study tracked 150 post-COVID-19 mucormycosis patients in the ICU from May 2021 to April 2022, revealing that 21% died, often linked to pneumonia and pulmonary embolism.
- Key risk factors for increased mortality included age over 60, steroid use, facial infections, uncontrolled diabetes, and high leukocyte counts.
Background: GLP-1 receptor agonists (GLP-1 RAs) have been shown to improve glycemic control and insulin sensitivity and reduce body weight in obese patients with type 2 diabetes mellitus (T2D). This trial sought to evaluate the therapeutic effect of oral and subcutaneous semaglutide in NAFLD and its sequelae in obesity and/or T2D.
Methods: In an open-labelled intervention study, the sample was 180 patients classified into three parallel groups (1:1:1): group I received oral semaglutide, group II patients received injectable semaglutide, and group III received pioglitazone and/or vitamin E.
The aim of this study was to assess the efficacy and safety of two protocols for retreatment of a cohort of Egyptian patients with chronic hepatitis C (CHC) who relapsed after NS5A inhibitor-based therapy. We conducted a prospective cohort study to assess the safety and efficacy of 12 weeks' retreatment with either combination of sofosbuvir/daclatasvir/simeprevir plus ribavirin (SOF/DCV/SMV/RBV, n = 45) or sofosbuvir/ombitasvir/paritaprevir/ritonavir plus ribavirin (SOF/OBV/PTV/r/RBV, n = 163) in patients who had previously failed NS5A inhibitors-based regimens. The primary end point was SVR 12 weeks after the end of treatment (SVR12).
View Article and Find Full Text PDFAssociated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis.
Intern Emerg Med
August 2019
The influence of vitamin D, 25-hydroxyvitamin D (25(OH)D), deficiency on hepatitis C virus (HCV)-related cirrhosis had been poorly elucidated especially in patients with hepatic encephalopathy (HE) and spontaneous bacterial peritonitis (SBP). We aimed to investigate the association between vitamin D deficiency and the risk of SBP or HE, including the mortality rate. Serum 25(OH)D levels were prospectively determined in 135 patients.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the phenomenon of occult hepatitis C infection (OCI) in Egyptian patients who achieved sustained virologic response (SVR) after treatment with direct-acting antiviral agents (DAAs).
- A total of 150 patients with chronic hepatitis C were tested for HCV RNA in their blood cells, revealing that 11.33% of them had positive results despite showing no active infection in serum.
- The research suggests that dual testing for HCV RNA in both serum and blood cells is essential to accurately assess the presence of OCI post-treatment, particularly after DAA therapy.