Multiple myeloma presenting as acute tubulointerstitial nephritis.

Background: Acute tubulointerstitial nephritis (ATIN) is a very rare paraneoplastic manifestation in patients with multiple myeloma (MM). It is an uncommon pattern of renal disease in such patients.

Case Presentation: We report a case of an 82-year-old male who was admitted with acute kidney injury.

Interstitial nephritis in melanoma patients secondary to PD-1 checkpoint inhibitor.

Background: Immune checkpoint inhibitors have become the first line therapy in melanoma treatment and their use is extending to other malignancies. However, we are still learning about immune side effects produced by these drugs and their severity especially in patients with history of inflammatory diseases.

Case Presentation: We present two cases of metastatic melanoma treated with nivolumab and pembrolizumab (anti PD-1).

Simplified prediction of postoperative cardiac surgery outcomes with a novel score: R2CHADS2.

Objective: To compare the accuracy of R2CHADS2, CHADS2, and CHA2DS2-VASc scores vs the Society of Thoracic Surgeons (STS) score as predictors of morbidity and mortality after cardiovascular surgery.

Methods: All patients who underwent cardiothoracic surgery at our institution from January 2008 to July 2013 were analyzed. Only those patients who fulfilled the criteria for STS score calculation were included.