Publications by authors named "Ayman A Alkhoder"
Article Synopsis
- Vitamin D deficiency (VDD) is linked to higher cardiovascular mortality and adverse outcomes in patients with coronary heart disease (CHD), potentially due to inflammation and impaired cell function.
- In a study involving over 5,400 individuals, those with VDD showed significantly increased risk of cardiovascular issues, especially when combined with high levels of inflammation and low counts of circulating progenitor cells (CPCs).
- The findings suggest that targeted interventions might be needed for those with both VDD and other risk factors, but more research is required to determine if supplementation can help reduce risks in these groups.
Aims: To investigate whether the adverse impact of lower educational attainment on mortality risk in patients with coronary artery disease (CAD) is mediated by the activation of inflammatory and immune pathways, estimated as elevated soluble urokinase plasminogen activator receptor levels.
Methods And Results: In 3164 patients undergoing coronary angiography, we investigated multivariable associations between suPAR and educational attainment and assessed the relationship between a lower educational level (defined as a high-school degree or less as the highest educational qualification) and outcomes using Cox proportional hazard and Fine and Gray's subdistribution competing risk models. The potential mediating effect through suPAR and high-sensitivity C-reactive protein (hs-CRP) was assessed using mediation analysis.
Importance: Previous studies have shown lower cardiovascular risk with higher high-density lipoprotein cholesterol (HDL-C) levels. However, recent data in the general population have shown increased risk of adverse outcomes at very high HDL-C concentrations.
Objective: To study the association between very high HDL-C levels (>80 mg/dL) and mortality in patients with coronary artery disease (CAD) and to investigate the association of known HDL-C genotypes with high HDL-C level outcomes.
Vascular Regenerative Capacity and the Obesity Paradox in Coronary Artery Disease.
Arterioscler Thromb Vasc Biol
June 2021
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View Article and Find Full Text PDFBackground Educational attainment is an indicator of socioeconomic status and is inversely associated with coronary artery disease risk. Whether educational attainment level (EAL) among patients with coronary artery disease influences outcomes remains understudied. Methods and Results Patients undergoing cardiac catheterization had their highest EAL assessed using options of elementary/middle school, high school, college, or graduate education.
View Article and Find Full Text PDFBackground Food deserts ( FDs ), defined as low-income communities with limited access to healthy food, are a growing public health concern. We evaluated the impact of living in FDs on incident cardiovascular events. Methods and Results We recruited 4944 subjects (age 64±12, 64% male) undergoing cardiac catheterization into the Emory Cardiovascular Biobank.
View Article and Find Full Text PDFBackground: Women with chest pain, ischemia, and no obstructive coronary artery disease often have coronary vascular dysfunction (CVaD). Peripheral vascular reactivity to mental stress may contribute mechanistic understanding of stress-induced ischemia in women with CVaD.
Methods: 62 women (41 CVaD and 21 controls) underwent mental stress testing (MST) with anger recall, mental arithmetic, and forehead cold pressor (COP) challenge.