Publications by authors named "Aylin S Crugnale"
Objectives: Nutrition plays a vital role in the outcome of critical illness in children, particularly those with acute kidney injury. Currently, there are no established guidelines for children with acute kidney injury treated with continuous kidney replacement therapy. Our objective was to create clinical practice points for nutritional assessment and management in critically ill children with acute kidney injury receiving continuous kidney replacement therapy.
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- Nutrition is crucial for critically ill children, especially those with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT), but there are no specific guidelines currently in place for their nutritional management.
- A comprehensive literature review was conducted, and insights from a panel of experts in pediatric nephrology and nutrition were utilized to create clinical practice points specifically focused on nutritional assessment and management for these patients.
- The final output includes 44 clinical practice points that address nutrition assessment, energy needs, and nutrient intake, developed through the modified Delphi method using existing research and expert consensus.
Among the various mechanisms that bacteria use to develop antibiotic resistance, the multiple expression of β-lactamases is particularly problematic, threatening public health and increasing patient mortality rates. Even if a combination therapy-in which a β-lactamase inhibitor is administered together with a β-lactam antibiotic-has proven effective against serine-β-lactamases, there are no currently approved metallo-β-lactamase inhibitors. Herein, we demonstrate that quercetin and its analogs are promising starting points for the further development of safe and effective metallo-β-lactamase inhibitors.
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