Inhibition of altered Orai1 channels in Müller cells protects photoreceptors in retinal degeneration.

The expressions of ion channels by Müller glial cells (MGCs) may change in response to various retinal pathophysiological conditions. There remains a gap in our understanding of MGCs' responses to photoreceptor degeneration towards finding therapies. The study explores how an inhibition of store-operated Ca entry (SOCE) and its major component, Orai1 channel, in MGCs protects photoreceptors from degeneration.

Cytotoxic effect of pyocyanin on human pancreatic cancer cell line (Panc-1).

Objectives: Pyocyanin, a blue-green pigment produced by , interferes with host redox cycles, which can lead to generation of reactive oxygen species and progressive cellular oxidative damage. The aim of this study was to assess the influence of pyocyanin on human pancreatic cancer cell line.

Materials And Methods: Polymerase Chain Reaction (PCR) was applied to confirm the existence of a specific pyocyanin producing gene (phzM).

Effect of fetal and adult bovine serum on pyocyanin production in isolated from clinical and soil samples.

Objectives: Pyocyanin is a blue-greenish redox-active pigment, produced by , with a wide range of biological and biotechnological applications. Pyocyanin biosynthesis is regulated by the quorum-sensing (QS) system in which the expression of QS genes and QS-controlled virulence genes may be affected by serum as a complex medium. In the current study, effects of adult bovine serum (ABS) and fetal bovine serum (FBS) on the production of pyocyanin were examined in order to develop it.