Interleukin-15 receptor blockade in non-human primate kidney transplantation.

Background: Interleukin (IL)-15 is a chemotactic factor to T cells. It induces proliferation and promotes survival of activated T cells. IL-15 receptor blockade in mouse cardiac and islet allotransplant models has led to long-term engraftment and a regulatory T-cell environment.

Intranodal palisaded myofibroblastoma; a case report and review of the literature.

Intranodal palisaded myofibroblastoma (IPM) also called as intranodal hemorrhagic spindle cell tumor with amianthoid fibers is a distinctive and rare mesenchymal neoplasm of lymph nodes. This entity generally misdiagnosed as intranodal Kaposi's sarcoma or schwannoma in past. In contrast to Kaposi's sarcoma, it behaves in a benign fashion and does not need any further therapy except total surgical resection of the mass.

Fournier's gangrene: is it scrotal gangrene?

Introduction: Fournier's gangrene was originally described as scrotal gangrene in young males. Today, it is generally accepted as synergistic necrotizing fasciitis of perineal, genital, or perianal regions, and the epidemiologic data have changed. However, there are still limited data about females due to the lack of female patients, even in large case series.

Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance.

We hypothesize that developmental exposure to noninherited maternal Ags (NIMA) results in alloantigen-specific natural and adaptive T regulatory (T(R)) cells. We compared offspring exposed to maternal H-2(d) (NIMA(d)) with nonexposed controls. In vitro assays did not reveal any differences in T cell responses pretransplant.

Treatment of Postherniorrhaphy Inguinal Abscess by Hydrofiber: A Possible Option of Leaving Mesh In situ?

The authors present a case of inguinal abscess occurring after inguinal hernia repair that was treated with a silver-containing wound care product without removing the prosthesis. A 75-year-old woman presented with inguinal abscess and acute renal failure initially underwent hemodialysis and then surgical drainage. The mesh was not removed, the wound was left open for secondary healing, and daily wound care was conducted using Aquacel Ag Hydrofiber® (ConvaTec, Skillman, NJ).