Publications by authors named "Ayham Zaza"
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology for which there are no approved therapeutic options. Patients with PSC display changes in gut microbiota and in bile acid (BA) composition; however, the contribution of these alterations to disease pathogenesis remains controversial. Here we identify a role for microbiota-dependent changes in BA synthesis that modulates PSC pathophysiology.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how liver fibrosis affects lobular zonation using mouse models and various fibrosis-inducing methods, revealing significant changes in gene expression between pericentral and periportal areas of the liver.
- - RNA sequencing and immunostaining showed a marked loss of pericentral proteins while periportal proteins began to be expressed in pericentral hepatocytes, a phenomenon termed 'periportalization.'
- - This periportalization pattern was consistent across all models and resulted in increased resilience against high doses of acetaminophen, while also highlighting the activation of inflammatory pathways and downregulation of estrogen-associated pathways in fibrotic livers.
Bile duct ligation (BDL) is an experimental procedure that mimics obstructive cholestatic disease. One of the early consequences of BDL in rodents is the appearance of so-called bile infarcts that correspond to Charcot-Gombault necrosis in human cholestasis. The mechanisms causing bile infarcts and their pathophysiological relevance are unclear.
View Article and Find Full Text PDF