This study examined how well different COVID-19 vaccines (BNT162b2, mRNA-1273, AZD1222, and Ad26.COV2.S) neutralize various SARS-CoV-2 variants, particularly among health care workers in the Netherlands.
Results showed that mRNA-1273 produced the highest neutralizing antibody levels, followed by BNT162b2, while adenovirus vector-based vaccines had significantly lower levels.
After a booster dose of BNT162b2, all vaccines improved their neutralizing abilities against variants, especially the Omicron variant, highlighting the importance of booster shots in enhancing vaccine effectiveness.
Emerging SARS-CoV-2 variants pose a threat to human immunity induced by natural infection and vaccination. We assessed the recognition of three variants of concern (B.1.