Publications by authors named "Ayesha Asbat"
Objective: The goal of the present study is to examine pretreatment with Schiff bases and derivatives of pregabalin along with their metal (Zn and Cu) complexes on the severity of epilepsy, latency time, duration of convulsions, seizure score and survival rate in mice.
Methods: To achieve the goal, a molecular docking study of analogues was carried out on a specific molecular target, such as the alpha-2δ receptor (PDB ID: 6ND9); which revealed the significant binding affinity of the analogs to their respective target. Based on the docking information, all pregabalin derivatives were synthesized and antiepileptic effect was confirmed by applying the PTZ model that prioritized the most crucial significant points responsible for biological activity.
Article Synopsis
- - Heavy metals and persistent organic pollutants harm the environment, primarily through industrial waste and emissions from incineration and combustion.
- - The review discusses various remediation strategies and bioremediation technologies, focusing on their effectiveness in both in situ (on-site) and ex situ (off-site) methods.
- - Combining bioremediation techniques with nanotechnology might offer a promising solution for effectively degrading heavy metals and organic pollutants.